| 引用本文:张桂灿，朱麒，张明，张雅琦，郑俩荣，关念红.虚汗停颗粒联合5-羟色胺选择性重摄取抑制剂治疗抑郁症临床观察[J].世界中医药,2023,(07):. |
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| 虚汗停颗粒联合5-羟色胺选择性重摄取抑制剂治疗抑郁症临床观察 |
| Clinical Observation of Xuhanting Granules Combined with Selective Serotonin Reuptake Inhibitor in the Treatment of Depression |
| 投稿时间：2022-11-04 |
| DOI：10.3969/j.issn.1673-7202.2023.07.021 |
| 中文关键词: 虚汗停颗粒 抑郁症 5-羟色胺选择性重摄取抑制剂 联合治疗 中成药 疗效评价 安全性评价 锥体外系反应 |
| English Keywords:Xuhanting Granules Depression Selective serotonin reuptake inhibitor Combination therapy Chinese patent medicine Efficacy evaluation Safety evaluation Extrapyramidal reaction |
| 基金项目:广东省科技计划项目-社会发展领域（2014A020212721）——重性精神障碍（双相障碍、精神分裂症）的社会功能损害与认知功能、脑结构改变相关性的对照研究；广东省自然科学基金-自由申请（2017A030313677）——儿童精神分裂症患者的长期预后、诊断稳定性及其影响因素研究 |
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| 中文摘要: |
| 目的：通过虚汗停颗粒联合5-羟色胺选择性重摄取抑制剂（SSRI）与单用SSRI比较，探究其安全性及对抑郁症患者健康相关生命质量的影响。方法：选取2017年1月至2019年12月中山大学附属第三医院收治的抑郁障碍急性发作患者95例作为研究对象，采用随机数字表法将患者分为观察组(n=46)和对照组(n=49)。对照组单用SSRI，观察组在对照组基础上联合口服虚汗停颗粒，2组均治疗8周。期间定期访视并测定抑郁自评量表（SDS）评分、健康调查量表36（SF-36）评分、哥伦比亚-自杀严重性评定量表（C-SSRS）评分、Barnes静坐不能量表（BAS）评分及异常不自主运动量表（AIMS）评分。结果：治疗8周后，与对照组比较，观察组患者SDS评分显著降低（P<0.01），而SF-36评分无显著性差异。在安全性方面，与对照组比较，观察组C-SSRS评分无显著性差异，而BAS及AIMS评分则显著降低（P<0.01）。结论：虚汗停颗粒联合SSRI类抗抑郁药治疗抑郁症患者，可以有效改善患者的社会功能，减少锥体外系不良反应，且安全性较高。 |
| English Summary: |
| To investigate the safety of Xuhanting Granules combined with selective serotonin reuptake inhibitor(SSRI) and the effect on health-related quality of life in patients with depression by comparing with SSRI alone.Methods:Ninety-five patients with acute depressive disorder treated in the Third Affiliated Hospital of Sun Yat-sen University from January 2017 to December 2019 were enrolled and randomly divided into an observation group(n=46) and a control group(n=49) according to the random number table method.The patients in the control group were treated with SSRI alone，and those in the observation group were treated with Xuhanting Granules combined with SSRI.Both groups were treated for eight weeks.Regular visits were carried out and the scores of the Self-Rating Depression Scale(SDS)，36-Item Short Form Survey(SF-36)，Columbia Suicide Severity Rating Scale(C-SSRS)，Barnes Akathisia Scale(BAS)，and Abnormal Involuntary Movement Scale(AIMS) were measured.Results:After eight weeks of treatment，the SDS score of the observation group was lower than that of the control group(P<0.01)，but the SF-36 score had no significant difference.In terms of safety，there was no significant difference in C-SSRS score between the two groups，while BAS and AIMS scores in the observation group were significantly lower than those in the control group(P<0.01).Conclusion:Xuhanting Granules combined with SSRI in the treatment of depression can effectively improve the social function of patients with depression and reduce extrapyramidal side effects with good safety. |
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