| 引用本文:陈佳阳1，殷玉琨1，张庆林2，李淏2，冯利1.基于数据挖掘的中药外用药辨治癌性疼痛治则治法分析[J].世界中医药,2023,(07):. |
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| 基于数据挖掘的中药外用药辨治癌性疼痛治则治法分析 |
| Data Mining for Medication Rules of External Application of Chinese Medicines Based on Syndrome Differentiation in the Treatment of Cancer Pain |
| 投稿时间：2021-06-03 |
| DOI：10.3969/j.issn.1673-7202.2023.07.024 |
| 中文关键词: 恶性肿瘤 癌性疼痛 中医药 外用中药 数据挖掘 辨证论治 治则治法 用药规律分析 |
| English Keywords:Malignant tumor Cancer pain Traditional Chinese medicine External application of Chinese medicine Data mining Treatment based on syndrome differentiation Therapeutic principles and methods Medication rule analysis |
| 基金项目:首都卫生发展科研专项项目（2020-2-4026）;中国医学科学院“中国健康长寿创新大赛”（2020-JKCS-001） |
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| 中文摘要: |
| 目的：基于数据挖掘分析方法探讨外敷中药治疗癌性疼痛的用药规律。方法：数据库检索外敷中药治疗癌性疼痛的临床研究或经验探析。将所用处方中的药物通过Excel建立数据库，通过药物、性味归经的频数分析，SPSS聚类分析，Clementine关联规则分析，探索用药规律。结果：共纳入187项研究，获得治疗恶性肿瘤骨转移及疼痛的中药处方190首，中药183味。药物频数分析中乳香、没药等应用最多；药物类别频数分析中，活血化瘀药最多；性味频数分析结果显示，温性药、寒性药及苦味药使用较多；归经以肝、脾、心3经最多；关联规则分析结果以没药，乳香等置信度最高；聚类分析得到药对7对，3味药药组1组。结论：外敷中药癌性疼痛遵循活血化瘀、温化痰饮及清心止痛等治疗原则。 |
| English Summary: |
| To reveal the medication rules of external application of Chinese medicines based on syndrome differentiation in the treatment of cancer pain by the data mining method.Methods:The related clinical studies or empirical analysis were retrieved from literature databases.A database of Chinese medicines used in the prescriptions was established in Excel.The use frequency，nature，taste，and tropism of the Chinese medicines were counted，and the cluster analysis in SPSS and the association rule analysis in Clementine were performed to explore the medication rules.Results:A total of 187 studies were included，involving 190 prescriptions and 183 Chinese medicines.Olibanum and Myrrha had the highest use frequency.The medicines with warm or cold nature，bitter taste，tropism to the liver，spleen，and heart meridians，and blood-activating and stasis-resolving activity had higher frequency.The results of association rule analysis showed that Olibanum and Myrrha had the highest confidence.The cluster analysis revealed 7 medicine pairs ad a three-medicine combination.Conclusion:External application of Chinese medicines for cancer pain follows the treatment principles of activating blood，resolving stasis，warming and resolving phlegm and fluid retention，and clearing heart to relieve pain. |
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