To explore the pharmacological mechanism of the compound Congrong Yizhi Capsule in treating vascular dementia.Methods:Based on the method of network pharmacology and molecular docking，the active ingredients of each drug in the compound Congrong Yizhi Capsule are obtained through the traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP)，and the targets of the active ingredients of the drug are predicted through the SwissTarget prediction database.The disease targets of vascular dementia are obtained through GeneCards，online Mendelian inheritance in man(OMIM)，and DRUGBANK databases.A protein-protein interaction(PPI) network is constructed with STRING 11.0 database and Cytoscape 3.8.0 to explore potential protein functional modules and core networks in the network; DAVID database is used to perform gene ontology(GO) enrichment analysis and Kyoto encyclopedia of genes and genomes(KEGG) pathway enrichment analysis，and Cytoscape 3.8.0 is adopted to construct the “drug-active ingredient-target-pathway” network diagram.In addition，molecular docking technology is employed to verify the results of the PPI network and the “drug-active ingredient-target-pathway” network diagram.Results:Thirty-five main active ingredients are screened，involving 134 targets.Among them，the main active ingredients include Armepavine，DFV，Isorhamnetin，etc.; key targets include amyloid precusor protein(APP)，PIK3CA，SRC，PIK3R1，MAPK1，TP53，MAPK3，JUN，AKT1，vascular endothelial growth factor A(VEGFA)，EGFR，F2，etc.; the biological pathways of compound Congrong Yizhi Capsule in treating vascular dementia act mainly in cancer signal pathway，Rap1 signal pathway，PI3K-AKT signal pathway，focal adhesion，Ras signal pathway，neuroactive ligand-receptor interaction，etc.The verification of the molecular docking results indicates that the main active ingredient has an excellent binding ability with the target.Conclusion:This study preliminarily reveals that the compound Congrong Yizhi Capsule may treat vascular dementia through multi-component，multi-target，and multi-channel cooperation，which provides a reference for the subsequent in-depth research.