| 引用本文:胡素叶1，李领娥1，柴旭亚1，杨盼盼1，白艳秋1，赵一丁2，李欣3.青黛膏治疗进行期银屑病血热证的临床效果观察[J].世界中医药,2023,(08):. |
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| 青黛膏治疗进行期银屑病血热证的临床效果观察 |
| Clinical Observation on Effect of Indigo Naturalis Ointment in Treating Psoriasis in the Active Stage of Blood-heat Syndrome |
| 投稿时间：2022-08-27 |
| DOI：10.3969/j.issn.1673-7202.2023.08.012 |
| 中文关键词: 银屑病；血热证；进行期；银翘三黄膏；青黛膏；白苓消银颗粒 临床观察 |
| English Keywords:Psoriasis Blood-heat syndrome Active stage Yinqiao Sanhuang ointment Indigo naturalis ointment Bailing Xiaoyin Granules Clinical observation |
| 基金项目:国家重点研发计划“中医药现代化研究”重点专项(2018YFC1705300）——银屑病“新血证论”理论体系构建与实践；河北省中医药管理局中医药类科研计划课题项目（2020329） |
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| 中文摘要: |
| 目的：评价外用青黛膏治疗进行期银屑病血热证的临床疗效和安全性。方法：选取2020年3月至2021年10月的石家庄市中医院皮肤科门诊收治的进行期血热证银屑病患者78例作为研究对象，按照随机数字表法分为观察组（n=40）和对照组（n=38）。所有患者采用白苓消银颗粒口服，观察组局部外用青黛膏，2次/d，对照组外用卡泊三醇软膏，2次/d。疗程均为8周。观察患者的客观皮损症状—银屑病皮损面积及严重程度指数（PASI）评分及主观瘙痒症状视觉模拟评分法（VAS）评分，记录患者的不良反应。结果：对于客观皮损症状PASI积分改善情况，观察组总有效率85%，明显高于对照组73.68%,差异有统计学意义（P<0.05）。对于主观瘙痒症状，观察组有效率为90.00%，高于对照组的71.05%,差异有统计学意义（P<0.05）。安全性方面，对照组2例患者出现了不同程度的刺激反应，外用润肤剂后局部症状缓解，观察组未出现不良反应。结论：青黛膏能够有效改善进行期银屑病血热证患者的客观皮损症状和主观瘙痒症状,不良反应少。 |
| English Summary: |
| To evaluate the clinical efficacy and safety of indigo naturalis ointment in treating psoriasis in the active stage of the blood-heat syndrome.Methods:A total of 80 patients with psoriasis(blood-heat syndrome) in the active stage were selected.According to the random number table，the patients were divided into the treatment group(40 cases) and the control group(38 cases).All patients were orally treated with Bailing Xiaoyin Granules.The treatment group was topically treated with indigo naturalis ointment twice a day，and the control group was topically treated with calcipotriol ointment twice a day.The course of the treatment was eight weeks.The objective skin lesion symptom，namely psoriasis lesion area and severity index(PASI) score was observed，and the visual analogue scale(VAS) score of subjective itching symptom was calculated.Adverse reactions of these patients were recorded.Results:The total effective rate for the PASI score of objective skin lesion symptom was 85% in the treatment group，which was significantly higher than that of the control group(73.68%)，and the difference(P<0.05) was statistically significant.As for subjective itching symptoms，the effective rate in the treatment group was 90%，which was higher than that of the control group(71.05%)，and the difference(P<0.05) was statistically significant.In terms of security，two patients in the control group had different degrees of irritation.After emollients were applied topically，local symptoms were relieved.All 40 patients in the treatment group completed the observation without any adverse reactions.Conclusion:Indigo naturalis ointment can effectively improve the objective skin lesion symptom and subjective itching symptom of patients with psoriasis in the active stage of blood-heat syndrome，with fewer adverse reactions. |
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