Based on the data mining analysis method，our study aims to explore the medication rule of traditional Chinese medicine(TCM) in the treatment of bone cancer pain(BCP).Methods:The database was searched for clinical studies or experiences of TCM in treating BCP.The TCM in the prescription was used to establish a database through Excel，and the medication rule of the medicine was explored through frequency analysis of property,flavor，and meridian of the medicine，SPSS cluster analysis，and Clementine association rule analysis.Results:A total of 97 studies were included，including 98 TCM prescriptions and 158 kinds of TCM.Frequency analysis of drug categories shows that herbs to tonify deficiency，activate blood circulation，and remove blood stasis are used the most，and frequency analysis of drugs indicates that Radix Rehmanniae Preparata，Fructus Psoraleae，Radix Glycyrrhizae，and Rhizoma Drynariae are applied the most.Flavor frequency analysis shows that warm，plain，sweet，bitter，and spicy herbs are often used.The liver，kidney，and spleen meridians are the most involved.Cluster analysis obtains nine drug pairs and two groups with three drugs.The results of the association rule analysis show that Radix Achyranthis Bidentatae and Cortex Eucommiae have the highest confidence.Conclusion:The treatment of BCP by TCM follows the principle of locally promoting blood circulation，removing blood stasis，and tonifying deficiency.Holistic treatment focuses on water metabolism，and herbs with warm properties can be used to dissolve phlegm.Meanwhile，the treatment adopts mild and warm drugs to maintain healthy qi.