| 引用本文:李杰1，王紫薇1，邓菊1，周春祥1，2.乌梅丸治疗结直肠癌可行性探讨[J].世界中医药,2023,(08):. |
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| 乌梅丸治疗结直肠癌可行性探讨 |
| Discussion on Feasibility of Wumei Pill in the Treatment of Colorectal Cancer |
| 投稿时间：2021-07-25 |
| DOI：10.3969/j.issn.1673-7202.2023.08.020 |
| 中文关键词: 中医药 乌梅丸 复法 药理作用机制 结直肠癌 网络药理学 多靶点 可行性分析 |
| English Keywords:Traditional Chinese medicine Wumei Pill Compound method Pharmacological mechanism Colorectal cancer Network pharmacology Multiple targets Feasibility analysis |
| 基金项目:国家自然科学基金面上项目（8207150756）——苓桂术甘汤干预脑淋巴引流防治AD的生物学机制；江苏高校中西医临床医学品牌专业建设工程资助项目（2020PPZXL261） |
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| 中文摘要: |
| 目的：对乌梅丸用于治疗结直肠癌的可行性进行探讨，以期能为结直肠癌的临床治疗提供参考依据，为更加深入的实验研究提供思路。方法：以临床实践观察所得为引，提出乌梅丸可用于结直肠癌治疗的观点，结合中医学对结直肠癌的认识，基于中医症状、病机、治则和现代中药药理学分析乌梅丸治疗结直肠癌的可行性，并运用现代生物信息技术对乌梅丸可能作用的靶点进行预测。结果：从中医理论以及现代药理学综合分析来看，乌梅丸具有良好的抗结直肠癌作用基础，网络药理学的结果也支持乌梅丸可能通过多成分、多靶点、多通路实现治疗结直肠癌的作用。结论：乌梅丸治疗结直肠癌有效，这为进一步的实验研究及临床运用提供了思路和理论依据。 |
| English Summary: |
| To explore the feasibility of Wumei Pill in the treatment of colorectal cancer，so as to provide a reference for the clinical treatment of colorectal cancer and offer ideas for further experimental research.Methods:Under the guidance of clinical practice and observation，this study presents the view that Wumei Pill can be used to treat colorectal cancer.In addition，according to traditional Chinese medicine understanding of colorectal cancer，the feasibility of Wumei Pill in the treatment of colorectal cancer is analyzed based on the traditional Chinese medicine symptoms，pathogenesis，therapeutic principle，and pharmacology of modern Chinese medicine.Modern bioinformation technology is adopted to predict the targets where Wumei Pill may act.Results:By comprehensively analyzing traditional Chinese medicine theory and modern pharmacology，It is found that Wumei Pill has excellent resistance to a colorectal cancer foundation，and the result of network pharmacology supports that Wumei Pill can treat colorectal cancer through multiple components，multiple targets，and multiple pathways，Conclusion:Wumei pill is effective in the treatment of colorectal cancer，which provides an idea and theoretical basis for further experimental research and clinical application. |
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