This study is based on the inheritance of traditional Chinese medicine(TCM) in Lingnan(south of the Five Ridges).By analyzing the medical records，this study summarized the medication rules and characteristics for chronic liver diseases(chronic hepatitis and liver cirrhosis) treated by famous and veteran TCM physicians in Lingnan.Methods:By searching the China national knowledge infrastructure(CNKI) database and the books in Guangzhou University of Traditional Chinese Medicine，the medical records written by famous and veteran TCM physicians in Lingnan in treating chronic liver diseases were collected，and SPSS modeler 15.0，Cytoscape 3.7.1，and other software were used for data mining of prescriptions in medical records.Results:Thirty two physicians and 157 prescriptions in medical records were found.The prescriptions involved 230 kinds of TCM，with Macrocephalae Rhizoma，Paeoniae Radix Alba，Radix Rhizoma Glycyrrhizae，Poria，Radix Bupleuri，and Salviae Miltiorrhizae as the core drugs.The result of system cluster analysis showed that the drugs used had the effects of strengthening vital qi，regulating qi-flowing，promoting blood circulation，clearing heat，promoting diuresis，softening hardness，and resolving accumulation.Conclusion:In the treatment of chronic liver diseases，famous and veteran TCM physicians in Lingnan adopted the methods of soothing the liver，invigorating the spleen，softening the liver，and promoting blood circulation，which were often combined with the products for clearing heat，detoxifying，dispelling dampness，eliminating icterus，softening hardness，and resolving accumulation.They also made good use of Chinese herbs in Lingnan，which had regional characteristics.