| 引用本文:关媛媛1，王东军2，田之魁2，孙璇2，步怀恩1，王泓午1.高血压中医证候研究的系统综述与Meta分析[J].世界中医药,2023,(09):. |
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| 高血压中医证候研究的系统综述与Meta分析 |
| Systematic Review and Meta-analysis of Traditional Chinese Medicine Syndromes of Hypertension |
| 投稿时间：2021-11-26 |
| DOI：10.3969/j.issn.1673-7202.2023.09.007 |
| 中文关键词: 高血压 中医证候 系统综述 Meta分析 质量评价 |
| English Keywords:Hypertension TCM syndromes Systematic review Meta-analysis Quality evaluation |
| 基金项目:国家重点研发计划中医药现代化研究重点专项（2017YFC1703305）——中医舌象诊断规范与标准研究及应用 |
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| 中文摘要: |
| 目的:通过系统评价高血压中医证候学特征，为高血压的中医辨证及治疗方案的制定及优化提供参考。方法：检索国家知识基础设施数据库（CNKI）、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)及中国生物医学文献数据库(CBM)，筛查参考文献，纳入高血压患者中医证候学的临床研究，研究类型为横断面研究。采用美国卫生保健质量和研究机构（AHRQ）评价工具和Stata 12分析软件进行质量评价和单组变量的Meta分析。结果：最终纳入36项研究，中医证候类型11个，其中阴虚阳亢证和气血两虚证发生率最高，分别为29%和29%，其次为痰瘀互结证27%。研究发现，肝火亢盛证16%（95%CI为0.15~0.18）、痰湿壅盛证31%（95%CI为0.29~0.34）、肾气亏虚证22%（95%CI为0.20~0.24）、肝阳上亢证10%（95%CI为0.80~0.12）发生率南方高于北方。肝火亢盛证13%（95%CI为0.12~0.13）、阴虚阳亢证28%（95%CI为0.27~0.29）、阴阳两虚证16%（95%CI为0.15~0.16）、肾气亏虚证18%（95%CI为0.16~0.20）、痰湿内阻证20%（95%CI为0.16~0.24）、瘀血阻络证14%（95%CI为0.13~0.15）、气血两虚证68%（95%CI为0.66~0.69）、肝肾阴虚证19%（95%CI为0.16~0.22）在有并发症患者中发生率较高。结论：本研究采用循证方法进行高血压中医证候研究，发现肾虚、血瘀证候为其常见证候，受地区和并发症的影响，高血压证型发生率存在差异。 |
| English Summary: |
| To provide a reference for the traditional Chinese medicine(TCM) syndrome differentiation of hypertension and the development and optimization of treatment strategies by systematically evaluating the characteristics of TCM syndromes of hypertension.Methods:The China National Knowledge Infrastructure(CNKI)，China Science Periodical Database(CSPD)，Chinese Citation Database(CCD)，and China Biology Medicine disc(CBMdisc) were systematically searched for related articles.Clinical research articles with a cross-sectional design on TCM syndromes in patients with hypertension were included.The Agency for Healthcare Research and Quality(AHRQ) evaluation tool and STATA 12 software were used for quality evaluation and meta-analysis of single group variable，respectively.Results:Finally，36 research articles were included.Eleven types of TCM syndromes were reported in the literature.Among them，the incidences of yin deficiency and yang hyperactivity syndrome and qi and blood deficiency syndrome were the highest，accounting for 29% and 29%，respectively，followed by combined phlegm and blood stasis syndrome with an incidence of 27%.The results found that the incidences of the following syndromes were higher in the south than in the north：liver-fire hyperactivity syndrome(16%，95%CI 0.15 to 0.18)，phlegm-dampness congestion syndrome(31%，95%CI 0.29 to 0.34)，kidney qi deficiency syndrome(22%，95%CI 0.20 to 0.24)，and liver-yang hyperactivity syndrome(10%，95%CI 0.80 to 0.12).The incidences of the following syndromes were higher in hypertensive patients with complications：liver-fire hyperactivity syndrome(13%，95%CI 0.12 to 0.13)，yin deficiency and yang hyperactivity syndrome(28%，95%CI 0.27 to 0.29)，yin and yang deficiency syndrome(16%，95%CI 0.15 to 0.16)，kidney qi deficiency syndrome(18%，95%CI 0.16 to 0.20)，phlegm-dampness internal obstruction syndrome(20%，95%CI 0.16 to 0.24)，blood stasis blocking collateral syndrome(14%，95%CI 0.13 to 0.15)，qi and blood deficiency syndrome(68%，95%CI 0.66 to 0.69)，and yin deficiency of liver and kidney syndrome(19%，95%CI 0.16 to 0.22).Conclusion:This study used evidence-based methods to investigate the TCM syndromes of hypertension and found that kidney deficiency syndrome and blood stasis syndrome were common syndromes of hypertension，and the incidence of hypertensive syndromes varied by region and complication. |
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