世界中医药
文章摘要
引用本文:田朝晖1,2,曾明月3,刘嘉4,杨超1,翁浩伟2,夏伟5,曾庆琪2,4.基于数据挖掘的中药复方治疗少弱精子症用药规律研究[J].世界中医药,2023,(09):.  
基于数据挖掘的中药复方治疗少弱精子症用药规律研究
Medication Laws of Traditional Chinese Medicine Compounds in the Treatment of Oligoasthenospermia Based on Data Mining
投稿时间:2022-02-25  
DOI:10.3969/j.issn.1673-7202.2023.09.016
中文关键词:  中药复方  少精子症  弱精子症  少弱精子症  数据挖掘  用药规律  五子衍宗丸  方剂运用
English Keywords:Traditional Chinese medicine compounds  Oligospermia  Asthenospermia  Oligoasthenospermia  Data mining  Medication laws  Wuzi Yanzong Pills  Prescription application
基金项目:第七批全国老中医药专家学术经验继承工作项目(国中医药人教函〔2022〕76号);江苏省教育厅2021年江苏高校“青蓝工程”中医药专业群教学团队项目(苏教师函〔2021〕11号);湖北省卫生健康委员会2018—2019中医药科研项目(ZY2019Q021)
作者单位
田朝晖1,2,曾明月3,刘嘉4,杨超1,翁浩伟2,夏伟5,曾庆琪2,4 1 恩施土家族苗族自治州中心医院恩施445099 2 南京中医药大学南京210023 3 南京大学南京211102 4 江苏卫生健康职业学院南京210029 5 南京市江宁医院南京211199 
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中文摘要:
      目的:运用数据挖掘技术,分析现代文献中运用中药复方治疗少弱精子症的用药规律。方法:检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、中国生物医学文献数据库(CBM)中运用中药复方治疗少弱精子症的临床研究文献,采用中医传承辅助软件(V3.0)进行统计分析。结果:纳入286首方剂,涉及248味中药,统计分析结果显示,少弱精子症最常见的证型是肾精亏损证;治疗少弱精子症的中药以温性药、平性药为主;药味以甘味药、苦味药居多;多归肾经、肝经、脾经;使用频次大于49次的药物有20味;同时出现在一个方剂中频次最高以及关联性最大的组合有6个;得到衍化新方3首。结论:治疗少弱精子症常用单味药物有枸杞子、菟丝子、淫羊藿、熟地黄、黄芪、当归、覆盆子、山药、五味子、车前子等;临床常以“对药”及“角药”形式配伍;常用方剂是五子衍宗丸。核心药物组合方1具有补肾填精,益气养血之功效;方2具有补肾填精,滋阴补血之功效;方3具有补肾填精,益气补血之功效。可供临床参考使用。
English Summary:
      To analyze the medication laws of traditional Chinese medicine(TCM) compounds in the treatment of oligoasthenospermia in modern literature by using data mining technology.Methods:The China National Knowledge Infrastructure(CNKI),China Science Periodical Database(CSPD),Chinese Citation Database(CCD),and China Biology Medicine disc(CBMdisc) were searched for clinical studies of oligoasthenospermia treated with TCM compounds.Statistical analysis was conducted using Traditional Chinese Medicine Inheritance Support System(TCMISS,V3.0).Results:There were 286 prescriptions included,involving 248 drugs.The results of statistical analysis showed that the most common syndrome of oligoasthenospermia was kidney essence deficiency syndrome.The drugs used for the treatment of oligoasthenospermia were mainly warm and mild in nature and sweet and bitter in flavor,acting on the kidney,liver,and spleen meridians.Twenty drugs were used more than 49 times.There were six combinations with the highest frequency and the greatest relevance in a prescription at the same time,where three new prescriptions were derived.Conclusion:The commonly used single drugs for the treatment of oligoasthenospermia are Lycii Fructus,Cuscutae Semen,Epimedii Folium,Rehmanniae Radix Praeparata,Astragali Radix,Angelicae Sinensis Radix,Rubi Fructus,Dioscoreae Rhizoma,Schisandrae Chinensis Fructus,Plantaginis Semen,etc.These drugs are commonly used in pairs as “pair drugs” or in combinations as ‘triangle drugs’ in clinical practice and the commonly used prescription is Wuzi Yanzong Pills.There are three prescriptions based on core drug combinations,all of which can help tonify the kidney and nourish kidney essence.Of them,prescription 1 can help invigorate qi and nourish blood.Prescription 2 can help replenish yin and blood.Prescription 3 can help tonify qi and replenish blood.These prescriptions can be used for clinical reference.
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