To analyze medication laws and mechanism of Chinese medicine in the treatment of coronary microvascular disease(CMVD) based on literature statistics and network pharmacology.Methods:Eight databases were searched for the literature on Chinese medicine against CMVD.SPSS Statistics 20.0 and SPSS Modeler 18.0 were used for association rule analysis，complex network diagram analysis，and cluster analysis of Chinese medicinal decoctions，and a core drug combination-active component-intersection target-pathway network was constructed.Results:A total of 184 research articles were screened out，with 70 prescriptions of Chinese medicinal decoctions involved，including 132 drugs，41 Chinese patent medicines，and 13 injections.Xuefu Zhuyu Decoction，Erchen Decoction，and Gualou Xiebai Banxia Decoction were reported frequently.The common oral Chinese patent medicines were Tongxinluo Capsules and Shexiang Baoxin Pills.The common Chinese medicinal injections included Danhong Injection.In Chinese medicinal decoctions，34 high-frequency drugs were included Chuanxiong Rhizoma，Angelicae Sinensis Radix，Salviae Miltiorrhizae Radix et Rhizoma，Bupleuri Radix，and Glycyrrhizae Radix et Rhizoma，with 18 types of functions of tonifying deficiency，regulating qi，releasing exterior，activating blood to resolve blood stasis，etc.The drugs were mainly sweet，pungent，and bitter in flavor，and warm and plain in property，acting on the liver，spleen，and lung meridians.Association rule analysis yielded 20 association rules.As revealed by cluster analysis，high-frequency drugs were classified into seven categories.Fourteen active components of core drug combinations were screened out，and there were 29 intersection targets of core drug combinations and CMVD.KEGG enrichment yielded 10 signaling pathways.Conclusion:Qi and blood play a vital role in the treatment of CMVD by traditional Chinese medicine(TCM)，and the therapeutic principles of TCM against CMVD are activating blood，resolving blood stasis，regulating qi，resolving phlegm，and dissipating mass combined with invigorating qi，activating yang，and reinforcing healthy qi.The core drug combinations can play an anti-CMVD role by regulating key targets such as PRKACA，ESR1，HSP90AA1，and NCOA1 through cancer pathway，estrogen signaling pathway，thyroid hormone signaling pathway，providing a reference for the prevention and treatment of CMVD.