With the development of science and technology，artificial intelligence technology represented by machine learning is gradually applied in the medical field.By discussing the application of machine learning in the treatment of encephalopathy，this paper illustrated that machine learning had a broad application prospect in the treatment of encephalopathy.The introduction of machine learning into the field of acupuncture and moxibustion against encephalopathy can facilitate data mining for clinical acupoint selection and prescription and predict the efficacy of acupuncture and moxibustion against encephalopathy，thereby clarifying the effectiveness and feasibility of machine learning in the field of acupuncture and moxibustion treatment of encephalopathy and providing a new direction for the development of acupuncture and moxibustion in the brain.This paper also pointed out the current problems and prospected the future trends to provide some references for the development of clinical and scientific research on acupuncture and moxibustion for the treatment of encephalopathy.