世界中医药
文章摘要
引用本文:秦妍1,包永睿1,2,王帅1,2,李天娇1,2,张秀君3,孟宪生1,2.肠道菌群对肝癌的作用机制及治疗研究进展[J].世界中医药,2023,(09):.  
肠道菌群对肝癌的作用机制及治疗研究进展
Research Progress on Mechanism and Treatment of Intestinal Flora in Liver Cancer
投稿时间:2021-09-08  
DOI:10.3969/j.issn.1673-7202.2023.09.021
中文关键词:  肠道菌群  肝癌  机制  肝-肠轴  胆汁酸代谢  炎症反应  信号通路  微生态系统
English Keywords:Intestinal flora  Liver cancer  Mechanism  Liver-gut axis  Bile acid metabolism  Inflammatory response  Signaling pathway  Microecosystem
基金项目:民族创新联合基金项目(2020-MZLH-35)
作者单位
秦妍1,包永睿1,2,王帅1,2,李天娇1,2,张秀君3,孟宪生1,2 1 辽宁中医药大学药学院沈阳110033 2 辽宁省中药多维分析专业创新技术中心/辽宁省现代中药研究工程实验室大连116600 3 丹东药业集团有限公司丹东118303 
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中文摘要:
      肠道菌群在生理条件下与宿主细胞存在着平衡的共生关系,始终处于动态、复杂的人体生态系统中,与人体健康密切相关。失衡的微生态系统对疾病的发生发展具有一定的促进作用,随着疾病的发生,人体肠道菌群的组成结构、菌群多样化也会随之改变。肠道细菌及其代谢物一方面通过影响肠上皮功能障碍以及胆汁酸代谢影响相关信号通路从而引发肝癌,另一方面通过肠-肝轴循环进入肝脏激活炎症反应相关信号通路从而促进肝癌的进展。目前,针对肠道菌群治疗肝癌的策略主要包括益生菌、粪便移植以及中医药治疗。现对肠道菌群对肝癌的发生发展机制以及治疗研究进展进行综述,对未来早期诊断、治疗肝癌患者,挽救患者生命具有重要作用。
English Summary:
      The intestinal flora exists in a balanced symbiotic relationship with host cells under physiological conditions,always in a dynamic and complex human ecosystem,and is closely related to human health.An imbalanced micro-ecosystem can to a certain extent contribute to the development of diseases.The composition and diversity of human intestinal flora will also change along with the onset of diseases.On the one hand,intestinal bacteria and their metabolites affect intestinal epithelial dysfunction with the effect of bile acid metabolism on related signaling pathways,thus causing liver cancer.On the other hand,they enter the liver through the “gut-liver axis” circulation and activate inflammation-related signaling pathways,which promotes the progress of liver cancer.At present,the treatment strategies for liver cancer aiming at intestinal flora mainly include probiotics,fecal transplantation,and traditional Chinese medicine treatment.In this paper reviewed the mechanism of intestinal flora on the pathogenesis and development of liver cancer and its role playing in the treatment of liver cancer,which is expected to play an important role in early diagnosis,treatment of liver cancer,and improving survival of cancer victims in the future.
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