| 引用本文:王秋铭，张雯静，刘世刚，李萌，李辉.支气管哮喘慢性持续期虚寒证候理论内涵[J].世界中医药,2023,(10):. |
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| 支气管哮喘慢性持续期虚寒证候理论内涵 |
| Theory of Chronic Duration of Bronchial Asthma with Deficiency-cold Syndrome |
| 投稿时间：2022-10-25 |
| DOI：10.3969/j.issn.1673-7202.2023.10.011 |
| 中文关键词: 支气管哮喘 慢性持续期 中医证候 虚寒证 中医理论 肺 脾 肾 |
| English Keywords:Bronchial asthma Chronic duration Traditional Chinese medicine syndrome Deficiency-cold syndrome Theory of traditional Chinese medicine Lung Spleen Kidney |
| 基金项目:国家自然科学基金面上项目（81573543）；中国中医科学院广安门医院所级科研基金创新重点项目（2019S444）；中国中医科学院育苗基金专项（ZZ11-074） |
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| 中文摘要: |
| 支气管哮喘慢性持续期的临床分型尚无统一标准，课题组前期对其中医临床表型进行了初步探索，发现虚寒证与虚热证之间在单核苷酸多态性（SNP）与甲基化基因表达与分布上有显著差异，现对慢性持续期虚寒证的理论基础和发病机制进行探讨。 |
| English Summary: |
| There is no unified standard for the clinical typing of chronic duration of bronchial asthma.We have preliminarily explored the traditional Chinese medicine clinical phenotype of this disease and found significant differences in the expression and distribution of single nucleotide polymorphism(SNP) and methylation genes between deficiency-cold syndrome and deficiency-heat syndrome.Here we expound the theoretical basis and pathogenesis of chronic duration of bronchial asthma with the deficiency-cold syndrome. |
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