| 引用本文:李媛1，刘殿娜2，代岳雯1，孙静宜2，胡凯文2.ⅢB-Ⅳ期非小细胞肺癌多中心回顾性队列研究[J].世界中医药,2023,(10):. |
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| ⅢB-Ⅳ期非小细胞肺癌多中心回顾性队列研究 |
| ⅢB-Ⅳ Stage Non-small Cell Lung Cancer:A Multicenter Retrospective Cohort Study |
| 投稿时间：2021-10-13 |
| DOI：10.3969/j.issn.1673-7202.2023.10.012 |
| 中文关键词: 冷消融 中药 化疗 治疗模式 生存分析 生命质量 评估 |
| English Keywords:Cryoablation Chinese medicine Chemotherapy Treatment mode Survival analysis Quality of life Assessment |
| 基金项目:国家重点研发计划项目（2018YFC1705102）；首都卫生发展科研专项项目（2018-1-4201） |
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| 中文摘要: |
| 目的：探讨冷消融联合中药及化疗对ⅢB-Ⅳ期非小细胞肺癌患者生存期及生命质量的影响。方法：采用多中心回顾性队列研究的方法，纳入ⅢB-Ⅳ期非小细胞肺癌患者，经中药联合冷消融治疗患者133例，经化疗患者40例。比较2组患者生存期，绘制Kaplan-Meier生存曲线，分析实验室检查及生命质量评分差异，比较2种治疗模式对患者的影响。结果：冷消融联合中药与化疗治疗ⅢB-Ⅳ期非小细胞肺癌2组患者生存期比较差异无统计学意义。结论：冷消融联合中药与化疗比较可以显著提高患者治疗后生命质量，改善不良反应，在一定意义上冷消融联合中药治疗模式可以替代化疗。 |
| English Summary: |
| To explore the effect of cryoablation combined with Chinese medicine and chemotherapy on the survival and quality of life of patients with stage ⅢB-Ⅳ non-small cell lung cancer.Methods:A multicenter retrospective cohort study was carried out.Patients with stage ⅢB-Ⅳ non-small cell lung cancer treated with cryoablation combined with Chinese medicine(n=133) or chemotherapy(n=40) were enrolled.The survival period of the patients in the two groups was compared and Kaplan-Meier survival curves were plotted.Differences in laboratory tests and quality of life scores were analyzed to compare the effect of the two treatment modes on patients.Results:There was no statistically significant difference in the survival period between the cryoablation combined with the Chinese medicine group and the chemotherapy group.Conclusion:Cryoablation combined with Chinese medicine significantly improved the quality of life of patients and reduced adverse reactions as compared with chemotherapy.In this sense，cryoablation combined with Chinese medicine treatment may be a replacement for chemotherapy. |
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