The Guidelines for Traditional Chinese Medicine Diagnosis and Treatment of Colorectal Cancer during Chemotherapy was initiated on December 1，2020 by the China Association of Chinese Medicine，drafted by 18 experts from 13 organizations nationwide，and officially released in July 2022 by the China Association of Chinese Medicine.The Guidelines has identified 5 clinical questions through the Delphi method and answered them via evidence-based medicine.Colorectal cancer，a common malignant tumor of the digestive tract，is mainly treated by chemotherapy.However，the adverse reactions limit the application of chemotherapy.Traditional Chinese medicine(TCM) has been proved effective in reducing the incidence of adverse reactions caused by chemotherapy and improving the completion rate of chemotherapy.Considering the confusion of clinicians，the editorial team carried out expert interviews，questionnaires，literature retrieval，and expert argumentation to formulate the Guidelines.This article details the background，significance，and core content of the Guidelines，and evaluates the consistency and practicality of the Guidelines through one case study.We hope that the TCM intervention can help more colorectal cancer patients benefit from chemotherapy，improve the completion rate of chemotherapy，and prolong the survival for colorectal cancer patients.A research team composed of experts and medical students involved in the drafting interprets the Guidelines.The personnel involved in the interpretation do not have any academic or commercial conflicts of interest related to the Guidelines.