To investigate the intervention effects of abdominal vibration manipulation on skeletal muscle tissue inflammation in a rat model of depression.Methods:Thirty-two rats were randomly divided into a normal group(n=8) and an experimental group(n=24).The rats in the experimental group underwent chronic unpredictable mild stress(CUMS) for three weeks for model induction.The model rats were further randomly divided into a model group，an abdominal vibration group，and a fluoxetine group.The intervention lasted four weeks，and behavioral tests were conducted at the end of the 7th week.Skeletal muscle tissue samples were collected from the rats to measure the levels of interleukin(IL)-1β，IL-4，IL-6，IL-8，IL-10，tumor necrosis factor(TNF)-α，as well as the protein and messenger RNA(mRNA) levels of silent information regulator 1(SIRT1)，peroxisome proliferator-activated receptor γ coactivator 1α(PGC-1α)，and nuclear factor κB(NF-κB).Results:At the end of the 7th week，compared with the model group，the abdominal vibration group showed improvements in sucrose preference，despair time，total distance moved，and the number of grid crossings(P<0.01).Additionally，compared with the model group，the abdominal vibration group showed increased levels of IL-4 and IL-10(P<0.01)，decreased levels of IL-1β，IL-6，IL-8，and TNF-α(P<0.01)，decreased NF-κB protein levels(P<0.05) and mRNA levels(P<0.01)，increased SIRT1 protein levels(P<0.01) and mRNA levels(P<0.01)，and increased PGC-1α protein levels(P<0.05) and mRNA levels(P<0.01).Conclusion:Abdominal vibration manipulation can improve depressive symptoms in a rat model of depression.The mechanism of action may involve inhibiting the expression of NF-κB protein in skeletal muscle tissue，promoting the expression of SIRT1 and PGC-1α proteins，thereby increasing the levels of anti-inflammatory factors and reducing the levels of inflammatory mediators.