| 引用本文:刘健1,2，张朝畅2，张盛琪1,2，王金环3，徐瑞荣4，杨淑莲5，王涛6，刘奇峰7，王海霞8，孙岸弢9，沈建平10，许亚梅11，李建英12，姚宇红13，丁晓庆14，史哲新15，周永明16，胡琦17，申小惠18，许勇钢2，刘风2，麻柔2，唐旭东2.补肾填精方联合西药治疗再生障碍性贫血血小板影响因素的预测研究[J].世界中医药,2023,(12):. |
|
| 补肾填精方联合西药治疗再生障碍性贫血血小板影响因素的预测研究 |
| Prediction of Platelet Influencing Factors in the Treatment of Aplastic Anemia by Bushen Tianjing Prescription Combined with Western Medicine |
| 投稿时间：2022-07-11 |
| DOI：10.3969/j.issn.1673-7202.2023.12.012 |
| 中文关键词: 再生障碍性贫血 补肾填精方 中西医结合治疗 血小板 影响因素 临床指标 预测研究 临床试验 |
| English Keywords:Aplastic anemia Bushen Tianjing Prescription Integrated traditional Chinese and western medicine treatment Platelet Influening factor Clinical indicators Prediction research Clinical trial |
| 基金项目:国家自然科学基金面上项目（82074258）；国家中医药管理局中医药行业科研专项（201507001-13）；中国中医科学院科技创新工程重大攻关项目（CI2021A01701） |
|
| 摘要点击次数: 381 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：观察补肾填精方联合西药治疗再生障碍性贫血（AA）对血小板（PLT）的影响，分析影响PLT的临床因素特征。方法：选取2018年9月至2021年3月中国中医科学院西苑医院、广安门医院等19个分中心的AA患者79例作为研究对象，以补肾填精方联合西药基础治疗，连用3个月为1个疗程，连续服用2个疗程，观察患者PLT变化情况，分析PLT较基线值增长且恢复正常、较基线值增长未恢复正常的AA患者的临床因素特征。结果：AA患者接受补肾填精方联合西药治疗4个月后，PLT较基线值增长且恢复正常的有13例，PLT较基线值增长未恢复正常的有66例。对一般资料分析显示，中医证候积分越低，补肾填精方联合西药治疗，PLT越容易恢复正常（P<0.05）。对治疗前血常规分析结果显示，治疗前血红蛋白≥60 g/L时、中性粒细胞数值越高时、网织红细胞比率＜0.5%时，补肾填精方联合西药治疗，PLT越容易恢复正常（P<0.05）。对治疗前T淋巴细胞亚群结果分析显示，CD3+CD19-＜60%时，以补肾填精方联合西药治疗，PLT更容易恢复正常（P<0.05）。结论：当AA患者的中医证候积分越低、血红蛋白≥60 g/L、中性粒细胞数值越高、网织红细胞比率＜0.5%、CD3+CD19-＜60%且越低时，以补肾填精方联合西药治疗，AA患者的PLT更容易增加并恢复正常（P<0.05）。 |
| English Summary: |
| To observe the effects of the Bushen Tianjing Prescription combined with western medicine on platelet(PLT) levels in patients with aplastic anemia(AA) and analyze the clinical factors influencing PLT.Methods:Seventy-nine AA patients from 19 participating centers，including Xiyuan Hospital and Guang'anmen Hospital of China Academy of Chinese Medical Sciences from September 2018 to March 2021 were enrolled.The patients received Bushen Tianjing Prescription combined with western medicine as the basic treatment.Each treatment course lasted three months，and the patients received two consecutive courses.The changes in PLT levels were observed，and the clinical factors of AA patients whose PLT increased from baseline and returned to normal and did not return to normal from baseline were analyzed.Results:After four months of treatment with Bushen Tianjing Prescription combined with western medicine，13 patients showed an increase in PLT levels that returned to normal，while 66 patients showed an increase in PLT levels but did not return to normal.General data analysis showed that the lower the traditional Chinese medicine(TCM) syndrome score，the easier the PLT recovery to normal with the treatment of Bushen Tianjing Prescription combined with western medicine(P<0.05).Pre-treatment blood routine analysis results indicated that when the hemoglobin level was≥60 g/L and the reticulocyte percentage was<0.5%，the higher the neutrophil count，the treatment with the Bushen Tianjing Prescription combined with western medicine resulted in a higher chance of PLT recovery to normal(P<0.05).The analysis of pre-treatment T lymphocyte subsets showed that when CD3+CD19- was<60%，the treatment with the Bushen Tianjing Prescription combined with western medicine resulted in a higher chance of PLT recovery to normal(P<0.05).Conclusion:For AA patients，a lower TCM syndrome score，hemoglobin level≥60 g/L，higher neutrophil count，reticulocyte percentage<0.5%，and CD3+CD19- <60% are associated with a higher likelihood of PLT increase and recovery to normal with the treatment of Bushen Tianjing Prescription combined with western medicine(P<0.05). |
| 查看全文 查看/发表评论 下载PDF阅读器 |
