| 引用本文:赵广珍1，丁秀芳2，陈文博1.复方苁蓉益智胶囊联合奥拉西坦治疗老年阿尔茨海默病的临床疗效[J].世界中医药,2023,(13):. |
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| 复方苁蓉益智胶囊联合奥拉西坦治疗老年阿尔茨海默病的临床疗效 |
| Clinical Efficacy of Compound Congrong Yizhi Capsules Combined with Oxiracetam in Treating Alzheimer's Disease |
| 投稿时间：2022-05-07 |
| DOI：10.3969/j.issn.1673-7202.2023.13.017 |
| 中文关键词: 阿尔茨海默病 老年 复方苁蓉益智胶囊 奥拉西坦 氧化应激 认知功能 炎症介质 神经递质 血液流变学 |
| English Keywords:Alzheimer's disease Elderly Compound Congrong Yizhi Capsules Oxiracetam Oxidative stress Cognitive function Inflammatory cytokines Neurotransmitter Blood rheology |
| 基金项目:国家自然科学基金青年科学基金项目（81503570） |
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| 中文摘要: |
| 目的：分析复方苁蓉益智胶囊联合奥拉西坦治疗老年阿尔茨海默病的临床疗效。方法：选取2018年1月至2021年9月北京市隆福医院收治的148例老年阿尔茨海默病患者作为研究对象，采用随机数字表法简单随机化分为对照组和观察组，每组74例。对照组采用奥拉西坦胶囊进行治疗，观察组在对照组的基础上联合复方苁蓉益智胶囊治疗，均治疗3个月。比较2组患者临床疗效、氧化应激指标、炎症介质、病情严重程度、胆碱能神经递质水平、血液流变学指标及简易精神状态量表（MMSE）评分。结果：治疗后，观察组总有效率高于对照组（P<0.05）。与治疗前比较，治疗后2组患者血清超氧化物歧化酶（SOD）、乙酰胆碱（ACh）、胆碱酯酶（AChE）水平、MMSE及画钟试验评分、即刻记忆、回忆、注意力及计算力、地点定向力、时间定向力、语言评分升高，观察组高于对照组（均P<0.05）；2组患者血清丙二醛（MDA）、白细胞介素-1β（IL-1β）、核因子κB水平及临床痴呆量表（CDR）评分、全血高切黏度、全血低切黏度、红细胞聚集指数降低，观察组低于对照组（均P<0.05）。结论：复方苁蓉益智胶囊联合奥拉西坦可有效减轻老年阿尔茨海默病患者机体炎症反应和氧化应激反应，缓解患者病情进展，调节神经递质水平和血液流变学，改善其认知功能，具有较好的治疗效果。 |
| English Summary: |
| To observe the clinical effect of Compound Congrong Yizhi Capsules combined with oxiracetam in treating Alzheimer's disease.Methods:A total of 148 elderly patients with Alzheimer's disease treated in Beijing Longfu Hospital from January 2018 to September 2021 were randomized into a control group(74 patients) and an observation group(74 patients) according to the random number table method.The control group was treated with oxiracetam capsules，while the observation group with oxiracetam capsules combined with Compound Congrong Yizhi Capsules.Both groups were treated for 3 months.The two groups were compared in terms of the clinical effect，the serum levels of oxidative stress indicators and inflammatory cytokines，severity of disease，cholinergic neurotransmitter level，hemorheological indicators，and Mini-Mental State Examination(MMSE) score.Results:The total response rate of the observation group was higher than that of the control group(P<0.05).The serum levels of superoxide dismutase(SOD)，acetylcholine(Ach)，and cholinesterase(AchE)，MMSE score，clock drawing test score，immediate memory，recall，attention，calculating capacity，place orientation，time orientation，and language elevated after treatment in both groups，and the observation group outperformed the control group(P<0.05).The serum levels of malondialdehyde(MDA)，interleukin-1β(IL-1β)，and nuclear factor-κB(NF-κB)，Dementia Scale(CDR) score，high-shear viscosity of whole blood，low-shear viscosity of whole blood，and erythrocyte aggregation index declined after treatment in the two groups and were lower in the observation group than in the control group(P<0.05).Conclusion:Compound Congrong Yizhi Capsules combined with oxiracetam can alleviate the inflammatory and oxidative stress responses to slow down the progression of the disease，regulate the neurotransmitter level and hemorheology，and improve the cognitive function，demonstrating a definite therapeutic effect on Alzheimer's disease. |
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