Diabetic retinopathy(DR) is one of the most serious complications of diabetes，severely damaging the retinal microvascular state and visual acuity of patients.Daming Decoction is an empirical prescription used to treat DR，which has been supported by extensive research in previous clinical and experimental studies.However，there is still a lack of specific elucidation on the mechanism of action of its main active components.Based on previous network pharmacology research，focusing on the active components in Daming Decoction，including quercetin，kaempferol，baicalein，luteolin，diosgenin，and beta-sitosterol，it was hypothesized that the main monomers in Daming Decoction exerted their effects in improving the non-proliferative and proliferative pathological changes of DR through mechanisms such as reducing blood glucose levels，resisting apoptosis，oxidation，and inflammation，protecting the optic nerve，reducing neovascularization，and improving retinal oxygen supply.By deeply elucidating the mechanism of action of the active components in Daming Decoction for the treatment of DR，this research aimed to fill the theoretical research gap，provide theoretical guidance for clinical medication and drug preparation，and potentially improve the overall therapeutic effect by enhancing the utilization of active components in the prescription.This research has significant practical implications.