| 引用本文:胡文悦1，韩振蕴1，王振亦2，常泽2，林景峰2，马华萍2，王育纯2.抑郁障碍与中医体质相关性研究的系统评价和Meta分析[J].世界中医药,2023,(14):. |
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| 抑郁障碍与中医体质相关性研究的系统评价和Meta分析 |
| Correlation Between TCM Constitution and Depressive Disorder：A Systematic Review and Meta-analysis |
| 投稿时间：2021-09-01 |
| DOI：10.3969/j.issn.1673-7202.2023.14.008 |
| 中文关键词: 中医体质 抑郁障碍 阈下抑郁 混合性焦虑抑郁障碍 系统评价 Meta分析 |
| English Keywords:TCM constitution Depressive disorder Subthreshold depression Mixed anxiety and depressive disorder Systematic review Meta-analysis |
| 基金项目:国家重点研发计划项目（2019YFC1710103）；深圳市医疗卫生三名工程项目（SZZYSM202105010） |
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| 中文摘要: |
| 目的：系统评价抑郁障碍中医9种体质分布情况，初步明确抑郁患者中医体质分布规律，为从体质角度防治抑郁提供一定参考。方法：计算机检索国家知识基础设施数据库、中国学术期刊数据库、中文科技期刊数据库、PubMed，纳入抑郁中医体质类型相关文献，应用R软件进行单个率的Meta分析，根据是否患病及程度分亚组应用RevMan 5.3软件分别进行Meta分析，结果以分布率、比值比(OR)及其95%置信区间表达效应值。结果：共纳入14项研究，10 484例样本。抑郁人群气郁体质占比27%，气虚体质占比26%，阈下抑郁人群气郁体质占比38%，气虚体质占比20%，组间比较气郁质、气虚质抑郁较非抑郁占比高有统计学意义，平和质非抑郁较抑郁占比高有统计学意义，气虚质在中重度抑郁较阈下抑郁分布比例高差异有统计学意义。文献质量评价总体偏低，存在偏倚风险。结论：气郁质、气虚质是抑郁人群主要体质类型，其与无抑郁人群存在明显差异，气虚质在中重度抑郁人群中更为多见，这可能成为调体质防治抑郁的切入点。 |
| English Summary: |
| To systematically evaluate the distribution of nine traditional Chinese medicine(TCM) constitutions in patients with depression and to preliminarily clarify the distribution patterns of TCM constitutions in patients with depression，providing a reference for the prevention and treatment of depression from the perspective of constitutions.Methods:China National Knowledge Infrastructure(CNKI)，China Science Periodical Database(CSPD)，Chinese Citation Database(CCD)，and PubMed were searched for relevant literature on TCM constitutions in depression.R software was used for Meta-analysis of single rates，and RevMan 5.3 software was used to conduct separate Meta-analyses for subgroups based on disease status and severity.The results were expressed as distribution rates，odds ratios(OR)，and their 95% confidence intervals.Results:Fourteen studies involving 10 484 participants were included.Among the depression population，the prevalence of the qi stagnation constitution was 27%，and the prevalence of the qi deficiency constitution was 26%.In the subpopulation with subthreshold depression，the prevalence of the qi stagnation constitution was 38%，and the prevalence of the qi deficiency constitution was 20%.The inter-group comparison revealed the prevalence of the qi stagnation and qi deficiency constitutions was significantly higher in the depression group than in the non-depression group.Conversely，the prevalence of the balanced constitution was significantly higher in the non-depression group than in the depression group.The prevalence of the qi deficiency constitution was significantly higher in the moderate-to-severe depression group than in the subthreshold depression group，showing a statistically significant difference.The overall quality of the literature was low，and there was a risk of bias.Conclusion:The qi stagnation and qi deficiency constitutions are the main constitution types in the depression population，showing significant differences compared with the non-depression population.The qi deficiency constitution is more common in the moderate-to-severe depression population，which may serve as an entry point for constitution-based prevention and treatment of depression. |
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