To explore the efficacy and safety of moxibustion treatment for essential hypertension.Methods:A total of 118 patients with essential hypertension admitted to Jiangxi Hospital of Traditional Chinese Medicine and the Second Affiliated Hospital of Jiangxi University of Chinese Medicine from May 2019 to December 2020 were enrolled and non-randomly divided into an observation group(n=61) and a control group(n=57) based on different treatment methods.The control group received the treatment plan before the study without any intervention，lasting for six months.The observation group also did not receive any intervention in the treatment plan before the study，lasting for six months，but received addtional moxibustion using moxibustion boxes on acupoints such as Baihui(GV20)，Zusanli(ST36)，Yongquan(KI1)，Dazhui(GV14)，Zhongwan(CV12)，Guanyuan(BL26)，Zhiyang(GV9)，and Shenshu(BL23).One to three acupoints were selected each time，and moxibustion was applied with 1-2 moxa sticks.The main outcome indicator was 24-hour ambulatory blood pressure，and the secondary outcome indicators were clinical symptom scores and the incidence of adverse events.Results:The symptoms in the observation group improved significantly compared with those in the control group，and the difference was statistically significant.However，there was no significant difference in 24-hour ambulatory blood pressure between the two groups before and after treatment.Five patients in the observation group experienced mild burns during the moxibustion procedure，but they recovered on their own after applying a burn ointment，and no infections or other complications were reported.Conclusion:The use of moxibustion boxes for moxibustion treatment in essential hypertension patients showed significant symptom improvement after six months，and the treatment was safe with no significant changes in blood pressure.