| 引用本文:曾奕斐1，权樱洁1，冯丹丹1，陈宏志1，李静蔚2.基于聚类分析中药治疗桥本甲状腺炎的用药规律[J].世界中医药,2023,(14):. |
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| 基于聚类分析中药治疗桥本甲状腺炎的用药规律 |
| Medication Rules of Chinese Medicine in the Treatment of Hashimoto's Thyroiditis Based on Cluster Analysis |
| 投稿时间：2021-09-03 |
| DOI：10.3969/j.issn.1673-7202.2023.14.018 |
| 中文关键词: 桥本甲状腺炎 中医 中药 聚类分析 文献统计 频数 用药规律 临床治疗 |
| English Keywords:Hashimoto's thyroiditis Traditional Chinese medicine Chinese medicine Cluster analysis Literature statistics Frequency Medication rules Clinical treatment |
| 基金项目:全国中医临床特色技术传承骨干人才培训项目(国中医药人教函〔2019〕36号)；山东省医药卫生科技发展计划项目(202016001022）；齐鲁卫生与健康领军人才项目（鲁卫人字〔2020〕3号） |
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| 中文摘要: |
| 目的：通过聚类分析等统计学方法研究分析中药治疗桥本甲状腺炎的临床用药特点及规律。方法：检索国家知识基础设施数据库（CNKI）、中国生物医学文献数据库（CBM）、中国学术期刊数据库（CSPD）、中文科技期刊数据库（CCD）及Pubmed数据库，将检索结果导入NoteExpress文献管理系统，筛选符合标准的文献，规范中药名称、格式，建立文献、方剂及中药信息表，利用Excel、SPSS 23.0对所得信息进行数据分析，包括频数统计、聚类分析等。结果：筛选出符合标准的文献129篇，共涉及方剂123首，中药144味，累计频数1 395次，单味药统计分析可知，补虚药使用频率最高，其中补气药尤甚。夏枯草、黄芪、浙贝母、白术使用频率最高，其中多为性温者，多属味苦、甘、辛，多归肝、脾、肾经。对38味高频药物聚类分析，得到8个常用药对及4个药物聚类组合，归纳总治则为疏肝理气、化痰散结、补益脾肾。结论：中药治疗桥本甲状腺炎多分期分证论治，以疏肝解郁为本，根据疾病进展分期分型兼以理气化痰、活血化瘀、温阳利水、补益脾肾。 |
| English Summary: |
| To analyze the clinical characteristics and rules of Chinese medicine in the treatment of Hashimoto's thyroiditis using statistical methods such as cluster analysis.Methods:China National Knowledge Infrastructure(CNKI)，China Biology Medicine(CBM)，China Science Periodical Database(CSPD)，Chinese Citation Database(CCD)，and PubMed were searched.The results were imported into the NoteExpress literature management system，and relevant literature that met the criteria was screened.Chinese medicine names and formats were standardized，and a database was established for literature，prescriptions，and Chinese medicine information.Excel and SPSS 23.0 were used to analyze the collected information，including frequency statistics and cluster analysis.Results:A total of 129 eligible research articles were selected，involving 123 prescriptions and 144 drugs，with a cumulative frequency of 1 395 applications.In the analysis of single drugs，the most frequently used drugs were deficiency-tonifying ones，especially qi-tonifying drugs.Prunellae Spica，Astragali Radix，Fritillariae Thunbergii Bulbus，and Atractylodis Macrocephalae Rhizoma were the most frequently used single drugs.They were mainly warm in nature，bitter，sweet，and pungent in flavor，and acted on the liver，spleen，and kidney meridians.Through cluster analysis of the 38 most frequently used drugs，8 common herbal pairs and 4 herbal clusters were obtained，and the overall treatment principles were summarized as soothing the liver，regulating qi，resolving phlegm，dissipating masses，and tonifying the spleen and kidney.Conclusion:Chinese medicine treatment for Hashimoto's thyroiditis is often based on syndrome differentiation according to different stages of the disease.The main focus is on soothing the liver and resolving depression，and treatment is further tailored based on disease progression and specific syndromes，including regulating qi，resolving phlegm，activating blood，resolving stasis，warming yang，promoting diuresis，and tonifying the spleen and kidney. |
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