Atherosclerosis(AS) is a chronic inflammatory disease caused by lipid deposition.The shedding of unstable plaque leads to thrombosis and even cerebrovascular events such as myocardial infarction and stroke.Transforming growth factor(TGF-β) signaling pathway is involved in the regulation of cell growth，differentiation，apoptosis，and other processes，playing a key role in the pathogenesis and treatment of AS.In recent years，the Chinese medical therapies targeting the TGF-β signaling pathway have been employed to regulate lipid deposition，ameliorate endothelial dysfunction，and stabilize plaques，alleviating the symptoms and improving the prognosis of AS patients.This paper summarizes the mechanisms of Chinese medical therapies in the prevention and treatment of AS via TGF-β signaling pathway，aiming to provide insights for the prevention and delay of AS and its complications.