The pathogenesis of stroke is a dynamic evolution process with the interactions between neurotoxicity and neuroprotection，and the proteins as signaling pathways involved in the interactions are usually activated by external stimuli.Studies have proved that acupuncture can inhibit ferroptosis of nerve cells in the brain after stroke to promote restoration of the neural function.In recent years，progress has been achieved in the regulation of ferroptosis-related signaling pathways by acupuncture after cerebral stroke.These pathways involve miR-23a-3p/erythroid-derived 2-like protein 2(NFE2L2)，p62/Kelch-like ECH-assocated protein 1(Keap1)/nuclear factor erythroid 2-related factor 2(Nrf2); α7nAChR-mediated Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3); cyclic adenosine monophosphate(cAMP)/cAMP-dependent protein kinase(PKA)/cAMP response element binding protein(CREB)，phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)，p38 mitogen-activated protein kinase(MAPK)，peroxisome proliferator-activated receptor-gamma coactivator-1 alpha(PGC-1α)/TFAM，and Notch and brain-derived neurotrophic factor(BDNF)-mediated Nrf2.Some of these signaling pathways have already been confirmed and others remain to be studied.