| 引用本文:赵琦1，李海松1，闫菲1，王继升1，米新宝2，赵聪1，张华南1，李曰庆1.基于高效指纹图谱和网络药理学的琥珀消石颗粒质量标志物预测[J].世界中医药,2023,(16):. |
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| 基于高效指纹图谱和网络药理学的琥珀消石颗粒质量标志物预测 |
| Q-marker Prediction of Hupo Xiaoshi Granules Based on High-efficiency Fingerprinting and Network Pharmacology |
| 投稿时间：2023-01-16 |
| DOI：10.3969/j.issn.1673-7202.2023.16.003 |
| 中文关键词: 琥珀消石颗粒 高效指纹图谱 网络药理学 质量标志物 槲皮素-3-O-(2G-α-L-鼠李糖基)-芸香糖苷 β-蜕皮甾酮 抗炎 抗氧化 |
| English Keywords:Hupo Xiaoshi Granules High-efficiency fingerprinting Network pharmacology Quality marker Quercetin-3-O-(2G-α-L-rhamnosyl)-rutinoside β-ecdysterone Anti-inflammatory Anti-oxidant |
| 基金项目:国家自然科学基金面上项目(82174385)；中华中医药学会青年求实项目(2021-QNQS-03) |
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| 中文摘要: |
| 目的：基于高效指纹图谱和网络药理学预测琥珀消石颗粒(HXG)中质量标志物(Q-Marker)。方法：构建HXG的高效液相色谱(HPLC)指纹图谱检测手段，指认共有峰和归属；应用网络药理学技术构建HXG的“成分-靶点-通路”网络图，预测其潜在Q-Marker。结果：HXG的指纹图谱结果共指认出5个共有峰；网络药理学确定了5种关键组成、35个潜在核心靶点和6条重要通路，初步预测槲皮素-3-O-(2G-α-L-鼠李糖基)-芸香糖苷、山柰酚-3-O-芸香糖苷、β-蜕皮甾酮、槲皮素、山柰素为HXG潜在的Q-Marker。结论：通过高效指纹图谱和网络药理学分析预测了HXG中的Q-Marker，方法科学并且可重复，为HXG的质量标准提供依据，也为今后系统研究其作用机制提供研究基础。 |
| English Summary: |
| To predict the quality markers(Q-markers) of Hupo Xiaoshi Granules(HXG) based on high-efficiency fingerprinting and network pharmacology.Methods:An high-performance liquid chromatography(HPLC) fingerprinting method was established to identify and assign the common peaks in HXG.Network pharmacology was applied to construct a “component-target-pathway” network to predict potential Q-markers in HXG.Results:The fingerprinting results of HXG identified five common peaks.The network pharmacology analysis revealed five key components，35 potential core targets，and six important pathways in HXG.Based on this analysis，the potential Q-markers of HXG were preliminarily predicted to be quercetin-3-O-(2G-α-L-rhamnosyl)-rutinoside，kaempferol-3-O-rutinoside，β-ecdysterone，quercetin，and kaempferol.Conclusion:The prediction of Q-markers in HXG using high-efficiency fingerprinting and network pharmacology analysis is a scientific and reproducible method，which can provide a basis for establishing the quality standards of HXG and serve as research foundation for future research on its mechanisms of action. |
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