| 引用本文:吴健1，袁军1，2，3，付彤飞1，阮冬冬1.6种中药注射剂联合激素治疗成人原发性肾病综合征的网状Meta分析[J].世界中医药,2023,(16):. |
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| 6种中药注射剂联合激素治疗成人原发性肾病综合征的网状Meta分析 |
| Network Meta-analysis of Six Kinds of Chinese Medicine Injection Combined with Hormones in Treatment of Adult Primary Nephrotic Syndrome |
| 投稿时间：2021-07-25 |
| DOI：10.3969/j.issn.1673-7202.2023.16.010 |
| 中文关键词: 中药注射剂 激素 联合用药 成人 原发性肾病综合征 网状Meta分析 系统评价 随机对照试验 |
| English Keywords:Chinese medicine injection Hormone Combination medication Adult Primary nephrotic syndrome Network Meta-analysis System evaluation Randomized control experiment |
| 基金项目:国家自然科学基金项目（82074364）；湖北省自然科学基金项目（2019CFB619）；湖北省卫生健康委科研项目（WJ2021M180） |
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| 中文摘要: |
| 目的：利用网状Meta分析比较6种中药注射剂联合激素治疗成人原发性肾病综合征的疗效。方法：检索国家知识基础设施数据库（CNKI）、中国学术期刊数据库（CSPD）、中文科技期刊数据库（CCD）、中国生物医学文献数据库(CBM)、Pubmed、Cochrane Library数据库中有关6种中药注射剂联合激素治疗成人原发性肾病综合征的随机临床对照试验,检索为建库至2021年4月，通过Stata 15.0软件对临床总有效率、血肌酐、24 h尿蛋白定量、总胆固醇、血浆白蛋白结局指标进行网状Meta分析。结果：共纳入文献28篇，共2 079例患者。在临床总有效率方面：银杏达莫注射液＞黄芪注射液＞肾康注射液＞丹参注射液＞丹红注射液＞疏血通注射液；在降低血肌酐方面：疏血通注射液＞丹参注射液＞黄芪注射液＞丹红注射液＞肾康注射液＞银杏达莫注射液；在降低24 h尿蛋白定量方面：肾康注射液＞银杏达莫注射液＞丹参注射液＞疏血通注射液＞黄芪注射液＞丹红注射液；在降低总胆固醇方面：肾康注射液＞黄芪注射液＞银杏达莫注射液＞疏血通注射液＞丹参注射液＞丹红注射液；在升高血浆白蛋白方面:肾康注射液＞丹红注射液＞银杏达莫注射液＞黄芪注射液＞丹参注射液＞疏血通注射液。结论：6种中药注射液联合激素治疗成人原发性肾病综合征对结局指标都有不同程度的改善作用，但由于纳入的文献有质量和数量上的差异，因此所得结果需结合临床运用。 |
| English Summary: |
| Network Meta-analysis was used to compare the efficacy of six kinds of Chinese medicine injection combined with hormones in the treatment of adult primary nephrotic syndrome.Methods:The six major databases，namely China National Knowledge Infrastructure(CNKI)，China Science Periodical Database(CSPD)，Chinese Citation Database(CCD)，China Biology Medicine Disc(CBM)，PubMed，and Cochrane Library were searched for the randomized controlled trial(RCT) of six kinds of Chinese medicine injection combined with hormones in the treatment of adult primary nephrotic syndrome.The retrieval time was from the establishment of each database to April 2021.The data of clinical total efficiency，blood creatinine，24-h urine protein，total cholesterol，and plasma albumin underwent network Meta-analysis by Stata 15.0 software.Results:A total of 28 studies involving 2 079 patients were included.The results of the network Meta-analysis showed that in terms of clinical total efficiency：Ginkgo Dammo injection>Astragalus injection>Shenkang injection>Danshen injection>Danhong injection>Shuxuetong injection; in terms of blood creatinine reduction：Shuxuetong injection>Danshen injection>Astragalus injection>Danhong injection>Shenkang injection>Ginkgo Dammo injection; in terms of 24-h urine protein reduction：Shenkang injection>Ginkgo Dammo Injection>Danshen injection>Shuxuetong injection>Astragalus injection>Danhong injection; in terms of total cholesterol reduction：Shenkang injection>Astragalus injection>Ginkgo Dammo injection>Shuxuetong injection>Danshen injection>Danhong injection; in terms of plasma albumi improvement：Shenkang injection>Danhong injection>Ginkgo Dammo injection>Astragalus injection>Danshen injection>Shuxuetong injection.Conclusion:The six kinds of traditional Chinese medicine injection combined with hormones in the treatment of adult primary nephrotic syndrome have different degrees of improvement in terms of indicators.However，due to the difference in quality and quantity of the included studies，the results need to be combined with clinical application. |
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