This study aims to observe the clinical efficacy and safety of Jieyu Capsule in treating geriatric depression.Methods:A total of 200 inpatients or outpatients from the Affiliated Hospital of Gansu University of Chinese Medicine from November 2020 to December 2021 were selected.According to the inclusion criteria，100 observation subjects，healthy control group of elderly people who came to the hospital for health examination，and 100 elderly people aged 60~80 years old for health examination were selected.Patients and healthy people were randomized into different groups.There were 37 males and 63 females in the observation group and 43 males and 57 females in the control group.The control group was treated with routine treatment，and the observation group was treated with TCM comprehensive therapy.The effects on non-invasive indexes such as score reduction before and after treatment，TCM syndrome analysis，medication and compliance，adverse reactions，and depression and anxiety factors in the two groups were analyzed.Results:The treatment effect on geriatric depression was mainly reflected in the reduction rate of the Hamilton Depression Scale and symptoms.After 12 months of combined treatment with TCM and anti-depression，the reduction rate of TCM syndrome scale in the two groups was 8.2±3.1 and 7.8±3.2，which was higher than that in the control group(8.8±3 and 8.4±3.6，and P values were 0.001 6 and 0.001 3).There were significant changes before and after treatment，with statistical significance.The reduction rate of the TCM syndrome scale(P<0.05) was statistically significant.From the perspective of adverse reactions after taking medicine，the TCM comprehensive treatment group should be significantly lower than the control treatment group，with statistical significance(P<0.05).From the analysis of the compliance of patients treated in the TCM group，there was statistical significance(P<0.05).Conclusion:The treatment effect of Jieyu Capsule combined with TCM is remarkable，and the compliance is better.