Based on data mining，this paper discussed the medication rules of traditional Chinese medicine(TCM) compound in the treatment of diarrhea-type irritable bowel syndrome(IBS-D) with liver depression and spleen deficiency syndrome.Methods:All clinical randomized controlled trials of TCM compound addition and subtraction in the existing literature database for the treatment of IBS-D with liver depression and spleen deficiency syndrome were retrieved，and TCM compounds with obvious curative effects were collected.A database after standardized processing of the data was established，and it was imported into the ancient and modern medical case cloud platform.Through the statistical analysis，association rule analysis，complex network analysis，and other methods in the data mining section，the frequency statistics，four properties and five flavors，and channel tropism of the included prescriptions were analyzed，and the core prescription was obtained.Results:A total of 122 documents meeting the requirements were retrieved，including 122 TCM compounds and 132 Chinese herbal medicines.The top five TCM used most frequently are Saposhnikoviae Radix，Citri Reticulatae Pericarpium，Poria Cocos，Paeoniae Radix Alba，and Bupleuri Radix.Among all TCM，medicines with flat nature have the highest frequency of use，followed by those with mild，slightly cold，and slightly warm natures.The common flavor is sweet，followed by pungent，bitter，sour，and mild.The channel tropism mainly belongs to the channels of the spleen，lung，liver，and stomach.Conclusion:The treatment of IBS-D with liver depression and spleen deficiency syndrome should use the medicine to disperse wind evil in the product of soothing the liver and strengthening the spleen and pay attention to the combination of cold and heat.