| 引用本文:庞晴1，李艳杰2，魏畅2，赵黎明1，倪青1.基于数据挖掘的倪青教授治疗甲状腺结节用药规律[J].世界中医药,2023,(16):. |
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| 基于数据挖掘的倪青教授治疗甲状腺结节用药规律 |
| Professor Ni Qing's Medication Rules for Thyroid Nodules Based on Data Mining |
| 投稿时间：2021-11-05 |
| DOI：10.3969/j.issn.1673-7202.2023.16.022 |
| 中文关键词: 甲状腺结节 瘿病 中医药 数据挖掘 关联规则 用药规律 @ 倪青 中医传承 |
| English Keywords:Thyroid nodules Gall disease Traditional Chinese medicine Data mining Association rules Medication rules @ Ni Qing Traditional Chinese medicine inheritance |
| 基金项目:国家中医临床研究基地开放课题(JD2019SZXZD08)——病证结合综合疗法对Graves病减毒增效缩短疗程验证研究 |
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| 中文摘要: |
| 目的：探究倪青教授治疗甲状腺结节的用药经验与组方规律。方法：收集并整理倪青教授2019年9月1日至2020年12月31日治疗甲状腺结节的医案处方，利用Microsoft Excel、IBM SPSS Modeler 18.0、IBM SPSS Statistics 22.0软件，对处方中药物的性味、归经、应用频次、药对组合等进行统计、关联规则及聚类分析等。结果：共收集倪青教授治疗甲状腺结节处方200首，中药193味，其中使用频次最高的前10味的药物为茯苓、苍术、甘草、大枣、厚朴、半夏、连翘、蒲公英、紫苏叶、山慈菇。药性以温、寒、平为多，药味以苦、甘、辛为多，归经以肝经、肺经、胃经及脾经为主。通过关联规则分析得到苍术与厚朴、茯苓与苍术、甘草与大枣、厚朴与半夏、茯苓与厚朴、大枣与生姜、山慈菇与猫爪草、连翘与浙贝母等常用药对。通过高频药物聚类分析得到4个聚类组，其中类3组（半夏、厚朴、紫苏叶、大枣）使用频率最高。结论：倪青教授治疗甲状腺结节以疏肝理气、化痰散结为基础，兼以活血化瘀、滋阴清热、补虚的临证经验相符。 |
| English Summary: |
| This study aims to explore Professor Ni Qing's medication experience and prescription rules for the treatment of thyroid nodules.Methods:Professor Ni Qing's medical records and prescriptions for the treatment of thyroid nodules from September 1，2019 to December 31，2020 were collected and sorted out.By using Microsoft Excel，IBM SPSS Modeler 18.0，and IBM SPSS Statistics 22.0 software，frequency statistics，association rules，and cluster analysis were performed on the nature，flavor，channel tropism，application frequency，and combination of drugs in prescriptions.Results:A total of 200 prescriptions for the treatment of thyroid nodules by Professor Ni Qing，including 193 traditional Chinese medicines，were collected.The top 10 most frequently used medicines were Poria Cocos，Atractylodes Lancea，Licorice，Jujubae Fructus，Magnolia Officinalis，Pinellia ternata，Forsythiae Fructus，Taraxacum，Perillae Folium，and Cremastrae Pseudobulbus.The medicinal properties are warm，cold，and calm，and the medicinal taste is bitter，sweet，and pungent.The main meridians are the liver meridians，lung meridians，stomach meridians，and spleen meridians.The commonly used drug pairs obtained through association rule analysis included Atractylodes Lancea and Magnolia Officinalis，Poria Cocos and Atractylodes Lancea，Licorice and Jujubae Fructus，Magnolia Officinalis and Pinellia ternata，Poria Cocos and Magnolia Officinalis，Jujubae Fructus and Zingiber Officinale Roscoe，Cremastrae Pseudobulbus and Ranunculi Ternati Radix，Forsythiae Fructus and Fritillariae Thunbrgii Bulbus，etc.Through the high-frequency drug cluster analysis，four cluster groups were obtained，among which the class 3 groups(Pinellia ternata，Magnolia Officinalis，Perillae Folium，and Jujubae Fructus) were used the most frequently.Conclusion:Professor Ni Qing treats thyroid nodules by soothing the liver，regulating qi，dissipating phlegm，promoting blood circulation，removing blood stasis，nourishing yin and clearing heat，and replenishing deficiency. |
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