| 引用本文:丁彤晶1,2，念家云1，张佳慧1,2，陈宇晗1,3，王秀慧1,3，于明薇1，王笑民1.基于数据挖掘的王笑民教授治疗非小细胞肺癌的用药规律[J].世界中医药,2023,(17):. |
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| 基于数据挖掘的王笑民教授治疗非小细胞肺癌的用药规律 |
| Medication Rules of Professor Wang Xiaomin for Treating Non-small Cell Lung Cancer Based on Data Mining |
| 投稿时间：2021-08-03 |
| DOI：10.3969/j.issn.1673-7202.2023.17.020 |
| 中文关键词: 非小细胞肺癌 中医药 数据挖掘 频数统计 聚类分析 关联规则 用药规律 @ 王笑民 |
| English Keywords:Non-small lung cancer Traditional Chinese medicine Data miming Frequency counting Cluster analysis Association rules Medication rules @ Wang Xiaomin |
| 基金项目:北京市自然科学基金资助项目（7202065）；2019年北京市落实中央引导地方科技发展专项（Z191100008319006）——恶性肿瘤常见并发症中医药规范化诊疗的示范推广应用 |
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| 中文摘要: |
| 目的：基于数据挖掘方法，对王笑民教授治疗非小细胞肺癌用药规律进行探究。方法：收集王笑民教授中医药治疗非小细胞肺癌病历资料并建立数据库，采用Excel、SPSS Statistics 25.0、SPSS Modeler18.0统计软件进行频数、聚类及关联规则分析等，对用药规律进行总结。结果：本研究纳入病例168例，男82例，女86例，年龄33~83岁，症状以咳嗽、咳痰、眠差等常见，中医辨证以瘀毒、相火妄动、脾虚等多见。纳入中药处方424首，涉及药物181味，高频中药29味，归经以肺、肝、脾为多，药性以寒、微寒、温为主，药味以甘、苦、辛多见。聚类分析得到5个药组。关联规则分析得到28条，白花蛇舌草-龙葵-白英-半枝莲-车前子，柴胡-法半夏-白芍，生黄芪-防风-炒白术常联合使用。症-证-药关联分析得出非小细胞肺癌患者以瘀毒证最为常见，常用半枝莲、白花蛇舌草、白英、龙葵、车前子。结论：王笑民教授治疗非小细胞肺癌，重在从肺、肝、脾论治，以清肺解毒、活血通滞、疏肝醒脾为治，明确邪正辨证关系及疾病发展的不同阶段，选择合适用药。 |
| English Summary: |
| To explore the medication rules of Professor Wang Xiaomin for treating non-small lung cancer based on the data mining method.Methods:We collected the records of Professor Wang Xiaomin in the treatment of non-small cell lung cancer and established a database.We then used Excel，SPSS Statistics 25.0，and SPSS Modeler 18.0 to analyze the herb use frequency and perform cluster analysis and association rules analysis.Results:A total of 168 patients were enrolled in this study，including 82 males and 86 females，with the age ranged from 33 to 83 years old.The patients mainly presented the symptoms of cough，expectoration，and poor sleep and the common syndromes of stasis，toxin，ministerial fire，and spleen deficiency.A total of 424 prescriptions were included，involving 181 herbs(including 29 with high frequency).The herbs mainly had tropism to the lung，liver，and spleen meridians，cold，mild cold，or warm nature，and sweet，bitter，or pungent taste.The cluster analysis yielded 5 herb combinations，and the association rules analysis yielded 28 association rules.Herba Hedyoti Diffusae-Herba Solani Nigri-Solanum Lyratum-Sculellaria Barbata-Plantain seed, Bupleuri Radix-Pinellinae Rhizomae Praeparatum-Root of Herbaceous Peony, Raw Milkvetch Root Saposhnikoviae Radix-fried Atractylodis Macrocephalae Rhizoma were commonly association rules.According to the analysis of the associations between syndromes，symptoms，and herbs，the syndrome of stasis and toxin was common among the non-small cell lung cancer patients，and the commonly used herbs were Scutellariae Barbatae Herba，Herba Hedyoti Diffusae，Herba Solani Lyrati，Herba Solani Nigri，and Plantaginis Semen.Conclusion:Professor Wang focuses on the lung，liver，and spleen in the clinical treatment of non-small lung cancer following the principle of clearing heat and removing toxin，activating blood and eliminating stagnation，and soothing the liver and invigorating the spleen.He uses different herbs in different disease stages according to syndrome differentiation. |
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