Insomnia is a sleep disorder characterized by difficulty initiating or maintaining sleep in the absence of physical，psychological，or medication-related factors，often leading to significant impairment in daytime functioning.It seriously affects the health and quality of life of insomnia patients.Insomnia is a disease that has not been fully understood.Metabolomics is a comprehensive analytical approach involving the analysis of all endogenous metabolites within a biological system and has been widely applied in various aspects of insomnia，including the discovery of diagnostic markers，disease prognosis，drug mechanisms of action，drug efficacy evaluation，and traditional Chinese medicine syndrome differentiation.This approach has yielded numerous research achievements in the field of insomnia.