| 引用本文:陈宇阳1，赵恒侠2，张靖悦1，连李荣1，李惠林2，刘德亮2，楚淑芳2.中成药联合口服降糖西药治疗2型糖尿病效果的网状Meta分析[J].世界中医药,2023,(18):. |
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| 中成药联合口服降糖西药治疗2型糖尿病效果的网状Meta分析 |
| Efficacy of Chinese Patent Medicine Combined with Oral Western Hypoglycemic Agents in the Treatment of Type 2 Diabetes Mellitus：A Meta-analysis |
| 投稿时间：2021-04-08 |
| DOI：10.3969/j.issn.1673-7202.2023.18.008 |
| 中文关键词: 网状Meta分析 系统评价 随机对照试验 疗效 中成药 口服降糖西药 2型糖尿病 |
| English Keywords:Meta-analysis System evaluation Randomized controlled trial Efficacy Chinese patent medicine Oral western hypoglycemic agent Type 2 diabetes mellitus |
| 基金项目:国家自然科学基金项目（81704002）；李惠林广东省名老中医药专家传承工作室建设项目；深圳市医疗卫生三名工程项目（SZSM201512043） |
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| 中文摘要: |
| 目的：评估临床常用的中成药分别联合常用口服降糖西药治疗2型糖尿病的有效性。方法：检索国家知识基础设施数据库（CNKI）、中国学术期刊数据库（CSPD）、中文科技期刊数据库（CCD）、中国生物医学文献数据库（CBM）、PubMed、Embase、Cochrane Library等数据库，文献时间范围为建库至2020年12月23日，根据纳入、排除标准进行文献筛选、资料提取并评价纳入研究的偏倚风险后，分别对不同结局指标包括空腹血糖、餐后2 h血糖、糖化血红蛋白采用网状Meta分析进行有效性比较及排序。结果：1)空腹血糖方面：7种中成药联合口服降糖西药均优于单纯口服降糖西药治疗，参芪降糖颗粒联用口服降糖西药疗效更为显著。2)餐后血糖方面：除消渴丸外，其余6种中成药联合口服降糖西药治疗效果均优于单纯口服降糖西药治疗，参芪降糖颗粒联用口服降糖西药疗效最为显著；3)糖化血红蛋白方面：除参芪降糖颗粒外，其余6种中成药联合口服降糖西药治疗效果均优于单纯口服降糖西药治疗，其中消渴丸疗效最佳。结论：7种中成药均能改善空腹血糖、餐后血糖、糖化血红蛋白，但由于临床试验的局限性，仍需要更多严谨、科学的临床试验为临床治疗提供切实有效的依据。 |
| English Summary: |
| To evaluate the efficacy of common Chinese patent medicines combined with common oral western hypoglycemic agents in the treatment of type 2 diabetes mellitus.Methods:China National Knowledge Infrastructure(CNKI)，Chinese Science Citation Database(CSPD) and Chinese Citation Database(CCD)，China Biology Medicine(CBM)，PubMed，Embase，and Cochrane Library were searched from the establishment of the database to December 23，2020.After literature screening and data extraction according to inclusion and exclusion criteria as well as the evaluation of the risk of bias of included studies,different outcome indexes including fasting blood glucose，2 h postprandial blood glucose and HbA1c were analyzed by Meta-analysis for the comparison of the efficacy.Results:In terms of fasting blood glucose，seven Chinese patent medicines combined with oral western hypoglycemic agents were superior to oral western hypoglycemic agents alone，and Shenqi Jiangtang Granule combined with oral western hypoglycemic agents had more significant efficacy.In view of 2 h postprandial blood glucose，except Xiaoke Pill，the therapeutic effect of the other six Chinese patent medicines combined with oral western agents was better than that of oral western agents alone，and Shenqi Jiangtang Granule combined with oral western agents had the most significant efficacy.Except Shenqi Jiangtang Granule，the other six Chinese patent medicines combined with oral western agents excelled in HbA1c when compared with single oral western agents，among which Xiaoke Pill had the optimal efficacy.Conclusion:The seven Chinese patent medicines can improve fasting blood glucose，postprandial blood glucose and HbA1c.Due to limited clinical trials，more rigorous and scientific clinical trials are needed to provide effective evidence for clinical treatment. |
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