| 引用本文:江南1，牧辰1，江孝华1，秦碧勇2.扶正祛邪养阴方辅助化疗治疗晚期气阴两虚型非小细胞肺癌患者的疗效[J].世界中医药,2023,(18):. |
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| 扶正祛邪养阴方辅助化疗治疗晚期气阴两虚型非小细胞肺癌患者的疗效 |
| Effect of Fuzheng Quxie Yangyin Decoction Supplemented with Chemotherapy in Treating Advanced Non-small Cell Lung Cancer of Qi-yin Deficiency |
| 投稿时间：2023-05-10 |
| DOI：10.3969/j.issn.1673-7202.2023.18.015 |
| 中文关键词: 扶正祛邪养阴方 多西他赛 顺铂 免疫功能 无进展生存期 非小细胞肺癌 肿瘤标志物 疗效 |
| English Keywords:Fuzheng Quxie Yangyin Decoction Docetaxel Cisplatin Immune function Progression-free survival time Non-small cell lung cancer Tumor markers Efficacy |
| 基金项目:湖北省卫生健康委员会2019～2020年度指导性项目(WJ2019F049) |
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| 中文摘要: |
| 目的：探讨扶正祛邪养阴方辅助化疗治疗晚期气阴两虚型非小细胞肺癌（NSCLC）患者的疗效。方法：选取2020年1月至2021年9月德驭医疗马鞍山总医院收治的晚期NSCLC患者120例作为研究对象，按照随机数字表法随机分为对照组和观察组，每组60例，对照组给予多西他赛+顺铂化疗，观察组在对照组基础上加用扶正祛邪养阴方治疗。比较2组患者间近期疗效，中医症状积分，肿瘤标志物血清糖类抗原125（CA125）、细胞角质素片段抗原21-1（CYFRA21-1）和癌胚抗原（CEA），免疫功能自然杀伤细胞(NK)、细胞毒T细胞(Tc)、和调节性T细胞(Treg)比例，生命质量（卡诺夫斯凯计分评分），不良反应及1年无进展生存期、无进展生存率及1年总生存率。结果：2组患者间疾病控制率、1年无进展生存期、无进展生存率及1年总生存率比较差异无统计学意义（P>0.05）；治疗后，观察组中医症状积分、肿瘤标志物（CA125、CYFRA21-1和CEA）、免疫功能（NK、Tc、和Treg比例）、卡诺夫斯凯计分评分和对照组差异均有统计学意义（均P<0.05），不良反应(胃肠道反应、骨髓抑制和肝功能异常)发生率显著低于对照组（P<0.05）。结论：扶正祛邪养阴方辅助化疗治疗晚期气阴两虚型NSCLC患者，能有效缓解临床症状，降低肿瘤标志物水平，提高免疫功能，降低不良反应发生率。 |
| English Summary: |
| To observe the effect of Fuzheng Quxie Yangyin Decoction supplemented with chemotherapy in the treatment of advanced non-small cell lung cancer(NSCLC) of qi-yin deficiency.Methods:A total of 120 patients with advanced NSCLC who were treated in the Maanshan General Hospital of Ranger-Duree Healthcare between January 2020 and September 2021 were selected and divided into control group(60 cases，docetaxel+cisplatin chemotherapy) and observation group(60 cases，Fuzheng Quxie Yangyin Decoction on the basis of control group) according to the random number table.The short-term efficacy，traditional Chinese medicine(TCM) symptom scores，tumor markers [serum carbohydrate antigen 125(CA125)，cytokeratin fragment antigen 21-1(CYFRA21-1)，carcinoembryonic antigen(CEA)]，immune function [proportions of natural killer cell(NK)，cytotoxic T cell(Tc) and regulatory T cell(TreGs)]，quality of life [Karnofsky Performance Status Scale(KPS) score]，adverse reactions，1-year progression-free survival time，progression-free survival rate and 1-year overall survival rate were compared between the two groups.Results:There were no differences in the disease control rate，1-year progression-free survival time，progression-free survival rate and 1-year overall survival rate between the two groups(P>0.05).After treatment，differences were found in the TCM symptom scores，tumor markers(CA125，CYFRA21-1，CEA)，immune function(proportions of NK，Tc and Treg) and KPS score between observation group and control group(P<0.05).The incidence of adverse reactions(gastrointestinal reactions，bone marrow suppression，abnormal liver function) in observation were lower than those in control group(P<0.05).Conclusion:Fuzheng Quxie Yangyin Decoction combined with chemotherapy can relieve the clinical symptoms，reduce tumor markers，improve the immune function，and lower adverse reactions in the treatment of patients with advanced NSCLC of qi-yin deficiency. |
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