| 引用本文:黄秋凌1，郑明翠2，宁娜1.乳核散结片抗炎镇痛的药理实验研究[J].世界中医药,2023,(22):. |
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| 乳核散结片抗炎镇痛的药理实验研究 |
| Pharmacological Study of Ruhe Sanjie Tablet for Anti-inflammation and Analgesia |
| 投稿时间：2023-05-29 |
| DOI：10.3969/j.issn.1673-7202.2023.22.007 |
| 中文关键词: 乳核散结片 抗炎 镇痛 疗效 药理实验 毛细血管通透性 结缔组织增生 乳癖消 |
| English Keywords:Ruhe Sanjie Tablet Anti-inflammation Analgesia Curative effect Pharmacological study Capillary permeability Connective tissue hyperplasia Rupixiao |
| 基金项目:广东省重点领域研发计划项目（2020B1111110004） |
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| 中文摘要: |
| 目的：探讨乳核散结片的抗炎及镇痛作用。方法：用SD大鼠棉球肉芽肿实验和二甲苯致小鼠毛细血管通透性增加实验，观察乳核散结片的抗炎作用；同时建立冰醋酸致小鼠扭体实验，观察乳核散结片的止痛作用。结果：乳核散结片低、中、高剂量组均能显著抑制大鼠肉芽增生，与空白对照组比较，差异均有统计学意义(均P<0.05)，其抑制率分别为30.0%、47.4%、53.6%，且呈量效关系。乳核散结片低、中、高剂量组均能有效降低小鼠毛细血管通透性，蓝斑光密度（OD）值与同期空白对照组比较，差异均有统计学意义(均P<0.001)，其对毛细血管通透性抑制率分别为47.6%、55.0%、65.2%，并呈量效关系。乳核散结片低、中、高剂量组均能有效减少冰醋酸致小鼠扭体次数(P<0.001)，其镇痛抑制率分别为34.2%、42.0%、51.5%，呈量效关系。结论：乳核散结片药理实验研究表明其具有抗炎及镇痛作用。 |
| English Summary: |
| To investigate the anti-inflammatory and analgesic effects of Ruhe Sanjie Tablet.Methods:Cotton pellet-induced granuloma formation of Sprague Dawley(SD) rats and the increase in capillary permeability of mice induced by xylene were used to observe the anti-inflammatory effect of Ruhe Sanjie Tablet.The acetic acid writhing experiment in mice was established to observe the analgesic effect of the prescription.Results:The low-，medium-and high-dose Ruhe Sanjie Tablet inhibited the proliferation of rat granulation tissue，and there were differences compared with the blank control group(all P<0.05).The inhibition rates of the three doses were 30.0%，47.4% and 53.6%，respectively，showing a dose-effect relationship.Ruhe Sanjie Tablet at low，medium and high doses reduced the capillary permeability of mice，and the optical density(OD) was lower than that in the blank control group(all P<0.001).The inhibition rates of capillary permeability were 47.6%，55.0% and 65.2%，respectively，with a dose-effect relationship.Ruhe Sanjie Tablet at each dose lowered the number of writhing induced by acetic acid in mice(P<0.001)，and the analgesic inhibition rates at low，medium and high dose were 34.2%，42.0% and 51.5%，respectively，presenting a dose-effect relationship.Conclusion:Pharmacological studies of Ruhe Sanjie Tablet indicates that it has anti-inflammatory and analgesic effects. |
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