Cancer pain is one of the most common and painful symptoms for patients with mid-to late-stage cancer，and it is also one clinical challenge to be solved.The pathogenesis of cancer pain is complex，and the three-step analgesic ladder promulgated by WHO is still being used，with unsatisfactory treatment effect.In recent years，studies on the treatment of cancer pain with integrative Chinese and western medicine have become wider and wider and shown desirable results.According to the theory of “cold qi generates turbidity” in Huangdi Neijing(Huangdi's Internal Classic)，this paper explored the microenvironmental pathogenesis of cancer pain，and proposed the idea of syndrome differentiation and treatment.In other words，the overall treatment should be based on reinforcing healthy qi and cultivating root; the pain relief should be based on tonifying yang and regulating qi; the local treatment should be based on dredging collaterals and resolving turbidity.This idea involves simultaneous treatment of the whole body and the local area，which provides a reliable theoretical basis for the treatment of cancer pain.