To analyse the effect of Yangxinshi Tablet on angina pectoris，anxiety and depression status in patients with chronic total occlusion(CTO) of the coronary artery.Methods:Seventy CTO patients with angina pectoris，anxiety and depression admitted to the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from September 2021 to May 2023 were selected as the study subjects.They were divided into observation group and control group using random number table method，with 35 in each group.The serum nitric oxide(NO)，seattle angina questionnaire(SAQ)，self-rating anxiety scale(SAS)，and self-rating depression scale(SDS) scores were used as outcome indexes.Results:After treatment，serum NO in observation group and control group was higher than that before treatment(P<0.05)，and the observation group was higher than the control group(P<0.05).Both group showed an increase in physical limitation(PL)，angina stability(AS)，angina frequency(AF)，treatment satisfaction(TS)，and disease perception(DP) of the SAQ scale compared with the pre-treatment level(P<0.05)，and the observation group was superior to the control group in PL，AS，AF，and TS(P<0.05)，while no difference was found in DP(P>0.05).The SAS and SDS scores of the two groups were lower than those before treatment(P<0.05)，with the observation group better than the control group(P<0.05).Conclusion:CTO easily leads to psycho-cardiological disease after intervention.Yangxinshi Tablet exerts significant effects in NO，SAQ，SAS and SDS，which is based on the academic ideas of nourishing by supplementing，unblocking，and tranquillizing.It improves the quality of life of patients with high safety，and thus can be used and promoted in clinical practice.