| 引用本文:刘冉1，2，王文礼3，高垣1，童秋瑜1，马文1，蔡娲1，桑珍4，沈卫东1，2.针灸治疗抑郁症的临床疗效与作用机制研究进展[J].世界中医药,2023,(22):. |
|
| 针灸治疗抑郁症的临床疗效与作用机制研究进展 |
| Clinical Efficacy and Mechanism of Acupuncture and Moxibustion for Depression：A Review |
| 投稿时间：2022-04-10 |
| DOI：10.3969/j.issn.1673-7202.2023.22.025 |
| 中文关键词: 针灸 抑郁症 临床疗效 作用机制 微RNA 突触可塑性 假针刺 随访研究 |
| English Keywords:Acupuncture and moxibustion Depression Clinical efficacy Mechanism MicroRNA Synaptic plasticity Sham acupuncture Follow-up study |
| 基金项目:国家自然科学基金项目（82004444）；上海市浦东新区卫生系统浦东名中医培养计划项目（PWRzm2020-05）——上海市浦东新区卫生系统名中医工作室建设项目；海派中医流派传承创新团队项目（2021LPTD-004）；上海市科学技术委员会科研计划项目（20Y21902900）；市级医院临床科技创新项目（SHDC22021210） |
|
| 摘要点击次数: 858 |
| 全文下载次数: 0 |
| 中文摘要: |
| 近年来，抑郁症的发病率逐年上升，危害性大，造成了严重的社会、经济负担，而临床上常用的抗抑郁药物疗效欠佳，且易产生耐药性。针灸凭借独特的优势在临床上广泛应用，取得较好的治疗效果。通过检索了近10年中英文文献，从临床疗效和作用机制研究等总结了针刺治疗抑郁症的相关研究。临床研究从普通针刺、电针、针药结合、灸法等疗法方面评价了针灸治疗抑郁症的疗效及安全性；作用机制研究从神经递质、神经内分泌-免疫、神经突触可塑性、脑源神经营养因子（BDNF）、信号通路及微RNA等探讨针刺治疗抑郁症的潜在作用机制。结果发现存在如评价标准不统一，假针刺对照设置，针刺防治抑郁症复发率等问题，研究质量仍需要进一步提高。 |
| English Summary: |
| In recent years，the incidence of depression has been increasing year by year，causing serious social and economic burdens.However，the commonly used antidepressant drugs have poor efficacy and are prone to drug resistance.Acupuncture and moxibustion is widely used in clinical practice for its unique advantages，and has achieved desirable therapeutic effects.The review summarized the related Chinese and English research on acupuncture treatment of depression in past decade from clinical efficacy and mechanism.Clinical studies evaluated the efficacy and safety of acupuncture and moxibustion in the treatment of depression from the aspects of ordinary acupuncture，electro-acupuncture，acupuncture-medicine combination，moxibustion and other therapeutic methods; the mechanism studies were carried out from neurotransmitters，neuroendocrine system-immunity，synaptic plasticity，brain-derived neurotrophic factor(BDNF)，signaling pathway and microRNA to explore the potential mechanism of acupuncture treatment of depression.The results found that there were some shortcomings，such as inconsistent evaluation criteria，unreasonable setting of sham acupuncture control，and recurrence in acupuncture prevention and treatment of depression.Research quality needs to be further improved. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
