| 引用本文:李冬霞1,2,3，王浩浩4，罗雪1,2，樊佳佳1,2，张纾难2.张纾难教授治疗肺结节的用药规律分析[J].世界中医药,2023,(23):. |
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| 张纾难教授治疗肺结节的用药规律分析 |
| Medication Rules of Professor ZHANG Shunan in the Treatment of Pulmonary Nodules |
| 投稿时间：2022-04-14 |
| DOI：10.3969/j.issn.1673-7202.2023.23.014 |
| 中文关键词: @ 张纾难 肺结节 中医传承辅助平台 用药规律 中药 寒温并用 清补兼施 数据挖掘 |
| English Keywords:@ ZHANG Shunan Pulmonary nodules Chinese medicine inheritance auxiliary platform Medication rules Traditional Chinese medicine Combination of cold and warm drugs Application of clearing and tonifying methods Data mining |
| 基金项目:国家自然科学基金项目（82104760）——基于miR-149-5p靶向调控Notch信号通路探讨鹿鹅鼻炎方干预变应性鼻炎的机制；国家区域（专科）中医诊疗中心建设（中医肺病）项目（2019—zx-004）；中日友好医院“菁英计划”人才培育工程项目（ZRJY2021-GG06）——肺结节的全程管理及中医药干预研究 |
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| 中文摘要: |
| 目的：分析总结张纾难教授治疗肺结节的用药经验与规律。方法：收集整理张纾难教授近4年来治疗肺结节的中药处方，利用中医传承辅助平台多维度分析处方药物的四气五味、归经、核心处方及药物群组。结果：对221首处方进行中药频次统计，共涉及171味中药，常用药物性味分别是温、寒，苦、辛；最常用归脾经、肝经、肺经药物；最常使用的药味为黄芪、桂枝、川贝母；常用药对是“生黄芪，桂枝”“生黄芪，川贝母”。关联规则分析得出由“黄芪、桂枝、川贝母、夏枯草、陈皮、郁金、生龙骨、生牡蛎、山慈菇”9味核心药物组成的关联网络，聚类分析得到4首新方。结论：张纾难教授在治疗肺结节时注重扶正以祛邪，寒温并用，清补共施，善用脾经、肝经、肺经药物，补脾益气，化痰散结，疗效确切。 |
| English Summary: |
| To analyze and summarize Professor ZHANG Shunan's experience and medication rules in the treatment of pulmonary nodules.Methods:The prescriptions for the treatment of pulmonary nodules by Prof.ZHANG Shunan in recent four years were collected，and the traditional Chinese medicine inheritance auxiliary platform was used to analyze the four qi and five flavors，meridian tropism，core prescription，and drug group of the prescription drugs in a multidimensional manner.Results:The frequency of traditional Chinese medicine is counted for 221 prescriptions，involving a total of 171 traditional Chinese medicine.The commonly used drugs are warm，cold，bitter，and pungent.The most commonly used drugs are for regulating the spleen meridian，liver meridian，and lung meridian.The most commonly used drugs are Astragalus membranaceus，Cinnamon Twig，and Sichuan bulb of fritillary.The commonly used drug pairs are “raw Astragalus，Cinnamon branch” and “raw Astragalus，Sichuan Fritillaria”.The association rule analysis obtains the association network composed of nine core drugs of “Astragalus membranaceus，Cinnamon Twig，Sichuan bulb of fritillary，Prunella vulgaris，Tangerine peel，Curcuma aromatica，Os draconis，Oyster Shells，and Bulbus Iphigenias”，and the cluster analysis obtains four new prescriptions.Conclusion:Professor ZHANG Shunan pays attention to strengthening the body resistance and eliminating pathogenic factors in the treatment of pulmonary nodules，with the cold and warm drugs used and clearing and tonifying methods applied.Professor ZHANG Shunan is good at using drugs for the spleen meridian，liver meridian，and lung meridian to tonify the spleen and benefit qi and resolve phlegm and disperse nodules，with remarkable effect. |
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