To analyze and summarize Professor ZHANG Shunan's experience and medication rules in the treatment of pulmonary nodules.Methods:The prescriptions for the treatment of pulmonary nodules by Prof.ZHANG Shunan in recent four years were collected，and the traditional Chinese medicine inheritance auxiliary platform was used to analyze the four qi and five flavors，meridian tropism，core prescription，and drug group of the prescription drugs in a multidimensional manner.Results:The frequency of traditional Chinese medicine is counted for 221 prescriptions，involving a total of 171 traditional Chinese medicine.The commonly used drugs are warm，cold，bitter，and pungent.The most commonly used drugs are for regulating the spleen meridian，liver meridian，and lung meridian.The most commonly used drugs are Astragalus membranaceus，Cinnamon Twig，and Sichuan bulb of fritillary.The commonly used drug pairs are “raw Astragalus，Cinnamon branch” and “raw Astragalus，Sichuan Fritillaria”.The association rule analysis obtains the association network composed of nine core drugs of “Astragalus membranaceus，Cinnamon Twig，Sichuan bulb of fritillary，Prunella vulgaris，Tangerine peel，Curcuma aromatica，Os draconis，Oyster Shells，and Bulbus Iphigenias”，and the cluster analysis obtains four new prescriptions.Conclusion:Professor ZHANG Shunan pays attention to strengthening the body resistance and eliminating pathogenic factors in the treatment of pulmonary nodules，with the cold and warm drugs used and clearing and tonifying methods applied.Professor ZHANG Shunan is good at using drugs for the spleen meridian，liver meridian，and lung meridian to tonify the spleen and benefit qi and resolve phlegm and disperse nodules，with remarkable effect.