Elemene is a sesquiterpene compound extracted from the traditional Chinese herb，namely zedoary turmeric.Elemene not only has strong anti-tumor activity but also shows good therapeutic effects on pain caused by various diseases.Studies have shown that elemene has an obvious analgesic effect and few side effects，and it has significant advantages compared with non-steroidal anti-inflammatory drugs (NSAIDs) causing gastrointestinal bleeding and allergy and opioids causing addiction，so it has high clinical application value.Recent studies have shown that the analgesic mechanism of elemene is multifaceted，including multiple methods，multiple pathways，and multiple targets，and the analgesic effect is significant.In addition，when elemene is used in combination with other drugs or analgesic methods，it can effectively relieve all kinds of pain and significantly improve the quality of life of patients.Therefore，this article summarized and reviewed the previous analgesic studies of elemene and highlighted the great potential of elemene in the treatment of chronic pain while comparing its efficacy and side effects with traditional analgesic drugs，so as to promote its further research and provide a reference for the rational selection of clinical analgesic drugs.