引用本文:宋玉莹1,崔琳2,何玉凤1,于莉莉1,祝慧颖1,刘卫红3.线粒体对心血管疾病铁死亡的影响及其中医药研究进展[J].世界中医药,2023,(23):. |
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线粒体对心血管疾病铁死亡的影响及其中医药研究进展 |
Effect of Mitochondria on Ferroptosis of Cardiovascular Diseases and Treatment with Traditional Chinese Medicine |
投稿时间:2023-01-18 |
DOI:10.3969/j.issn.1673-7202.2023.23.026 |
中文关键词: 铁死亡 线粒体 心血管疾病 中医药 脂质过氧化 活性氧 作用机制 研究进展 |
English Keywords:Ferroptosis Mitochondria Cardiovascular diseases Traditional Chinese medicine Lipid peroxidation Reactive oxygen species Mechanism Research progress |
基金项目:国家自然科学基金青年科学基金项目(81703897);河南省科技攻关计划项目(192102310171);河南省中医药科学研究专项课题(2022ZY1021) |
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中文摘要: |
心血管疾病是严重威胁人类健康的循环系统疾病,具有发病率、致残率和死亡率高的特点。铁死亡作为一种新型细胞死亡方式,与脂质、铁、氨基酸代谢密不可分。线粒体形态学作为铁死亡的特征改变,其与铁死亡的发生机制关联密切。通过介绍铁死亡发生机制、线粒体在铁死亡中的作用、心血管疾病中二者间相互作用及中医药治疗,这有助于了解铁死亡相关性疾病并寻找新的治疗靶点。 |
English Summary: |
Cardiovascular disease is a circulatory system disease seriously threatening human health.It is characterized by high morbidity,disability,and mortality.As a new cell death mode,ferroptosis is closely related to lipid,iron,and amino acid metabolism.Mitochondrial morphology,as a characteristic change of ferroptosis,is highly related to the mechanism of ferroptosis.By introducing the mechanism of ferroptosis,the role of mitochondria in ferroptosis,the interaction between mitochondria and ferroptosis in cardiovascular diseases,and the treatment of traditional Chinese medicine,it is helpful to understand the diseases related to ferroptosis and find new therapeutic targets. |
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