| 引用本文:张瑶，付兴，侯鉴宸，周冉冉，杨凤，李芊芊，葛飞，罗亚敏，陶晓华.基于《中医方剂大辞典》挖掘古代治疗偏头痛的用药和时代规律[J].世界中医药,2024,(01):. |
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| 基于《中医方剂大辞典》挖掘古代治疗偏头痛的用药和时代规律 |
| Prescription and Age Laws of Ancient Migraine Treatment Based on the Dictionary of Traditional Chinese Medicine Prescriptions |
| 投稿时间：2022-05-10 |
| DOI：10.3969/j.issn.1673-7202.2024.01.001 |
| 中文关键词: 偏头痛 数据挖掘 中医方剂大辞典 古今医案云平台 用药规律 时代规律 关联规则 复杂网络 |
| English Keywords:Migraine Data mining Dictionary of Traditional Chinese Medicine Prescriptions The Ancient and Modern Medical Records Cloud Platform Prescription law Age laws Association rules Complex network |
| 基金项目:国家自然科学基金面上项目（81974542）——基于TRPV1/p-ERK/COX-2信号通路研究偏痛汤1号抑制神经源炎性痛敏性偏头痛的分子机制 |
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| 中文摘要: |
| 目的：通过收集整理《中医方剂大辞典》中治疗偏头痛的古代方剂，挖掘其用药和时代规律，为临床治疗偏头痛提供参考。方法：从《中医方剂大辞典》中筛选出符合标准的方剂，导入古今医案云平台，统计不同时代药物种类、四气、五味、归经和功效频率，运用复杂网络分析和关联分析挖掘治疗偏头痛的核心中药和药物关联情况。结果：共筛选出266首方剂，涉及337种中药，各年代方药不全相同，但均喜用温性、苦味或辛味，归肺、肝或脾的中药。其中，最核心的中药为川芎、防风和当归，并常用甘草、细辛、防风和川芎相配伍。结论：各年代医家辨治偏头痛用药不尽相同，但其用药思想包括性味归经等基本相同，从汉唐至清代整体一脉相承，总不离祛风、活血、止痛和从肝论治，可为现代临床治疗偏头痛提供重要参考。 |
| English Summary: |
| To collect and sort out the ancient prescriptions for migraine in the Dictionary of Traditional Chinese Medicine Prescriptions，and excavate the prescription and age laws，to provide reference for the clinical treatment of migraine.Methods:The prescriptions that met the standards were screened from the Dictionary of Traditional Chinese Medicine and entered into the Ancient and Modern Medical Records Cloud Platform.The types of herbal medicines，four qi，five flavors，meridian tropism and efficacy frequency in different ages were counted.Complex network analysis and association analysis were used to mine the core Chinese herbal medicines and herb associations in migraine treatment.Results:A total of 266 prescriptions were screened out，involving 337 Chinese herbal medicines.Although the prescriptions varied in different dynasties，they were all warm，bitter or pungent and acted on the lung，liver.or spleen.Among them，the most core herbs were Rhizoma Chuanxiong，Radix Saposhnikovia and Radix Angelicae Sinensis，and Radix et Rhizoma Glycyrrhizae，Radix et Rhizoma Asari，Radix Saposhnikovia and Rhizoma Chuanxiong were commonly combined.Conclusion:Different prescriptions were applied in migraine treatment by ancient physicians in different ages，but with the same prescription ideas including nature，flavor，and meridian tropism.From Han and Tang Dynasties to Qing Dynasty，the treatment was carried out from dispelling wind，activating blood，and relieving pain based on liver.This paper provide key reference for the modern clinical treatment of migraine. |
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