| 引用本文:姜晓丹1，崔欣怡1，油红捷2，唐佐青2，马赟1，杨铮1，车念聪1，刘文兰1.基于《中华医典》文献挖掘中医治疗积聚的用药规律研究[J].世界中医药,2024,(01):. |
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| 基于《中华医典》文献挖掘中医治疗积聚的用药规律研究 |
| The Medication Rule of Traditional Chinese Medicine for the Treatment of Abdominal Masses Based on Data Mining in Chinese Medical Code |
| 投稿时间：2022-04-30 |
| DOI：10.3969/j.issn.1673-7202.2024.01.001 |
| 中文关键词: 中华医典 积聚 肿瘤 数据挖掘 中药方剂 用药规律 关联规则 聚类分析 |
| English Keywords:Chinese medical code Abdominal mass Tumour Data mining Herbal prescription Medication rule Association rules Cluster analysis |
| 基金项目:国家自然科学基金项目（81573879）；北京市自然科学基金项目（7182021） |
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| 中文摘要: |
| 目的：探讨《中华医典》中治疗积聚方剂的用药特点及其规律。方法：检索《中华医典》治疗积聚的方剂，按照纳入和排除标准筛选治疗积聚的方剂，建立Excel数据库，进行用药频次、性味、归经分析。并使用R语言arules包及arulesViz包对筛选处方中的药物进行关联规则分析及可视化,使用IBM SPSS Modeler 18.0对药物进行复杂网络分析，采用SPSS Statistics 26.0对聚类方剂进行分析。结果：筛选后共纳入方剂426首，包含中药303种，总用药频次4 075次；四气9种，总频次3 214次；五味8种，总频次5 490次；十二经总频次11 936次。治疗积聚应用频次较高的药物前3位为木香、肉桂、当归；关联性药对以三棱、木香出现频次最高。复杂网络分析，木香-肉桂、木香-三棱之间的关联性较强。聚类图谱显示，皮尔逊相关性为20时，高频药物可聚为5类。结论：历代医家在积聚治疗时，所用药物药性以温性为主，药味以辛味和苦味为主，归经侧重于脾胃经，功效以理气药、温里药、补益药为主。通过对《中华医典》中治疗积聚的用药规律研究，为临床实践中药治疗积聚相关疾病提供参考。 |
| English Summary: |
| To explore the characteristics and medication rules of the prescriptions for the treatment of abdominal masses in Chinese Medical Code.Methods:The prescriptions for the treatment of abdominal masses in the Chinese Medical Code were retrieved，and screened according to inclusion and exclusion criteria，and an Excel database was established to analyze frequency of medication，properties，taste and meridian tropism.The arules and arulesViz packages in R language were used for association rule analysis and visualization of screened prescriptions.IBM SPSS Modeler 18.0 software was used for complex network analysis，and SPSS Statistics 26.0 software was used for cluster analysis of the prescriptions.Results:A total of 426 prescriptions were selected，containing 303 types of herbs，with a total frequency of medication of 4075 times.There were four properties in 9 types of herbs with a total frequency of 3 214 times.There were five flavors in 8 types of herbs with a total frequency of 5 490 times.The total frequency of Twelve channels was 11 936.The top 3 drugs with high frequency of application in the treatment of abdominal masses were Muxiang，Rougui and Danggui.The drug pair with the highest correlation was Sanleng-Muxiang.According to the complex network analysis，the correlation between Muxiang-Rougui and Muxiang-Sanleng was strong.The cluster map showed that when Pearson's correlation was 20，drugs could be clustered into 5 categories.Conclusion:In the treatment of abdominal masses by doctors in the past dynasties，the drugs used were mainly warm in nature，and spicy and bitter in taste.The meridians focus on the spleen and stomach meridians，and their effects mainly include regulating qi，warming interior，and tonifying the body.Through the study of the medication rule in the treatment of abdominal masses in Chinese Medical Code，it provides a reference for the summary of clinical practice of traditional Chinese medicine in the treatment of abdominal mass-related diseases. |
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