| 引用本文:李梦媛，张乃文，李小黎，鲁丽华，张婧，刁华琼，陈琳.从“补肾疏肝”论治女性更年期抑郁症[J].世界中医药,2024,(01):. |
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| 从“补肾疏肝”论治女性更年期抑郁症 |
| Treatment of Female Climacteric Depression from the Theory of “Tonifying the Kidneys and Soothing the Liver” |
| 投稿时间：2022-05-16 |
| DOI：10.3969/j.issn.1673-7202.2024.01.001 |
| 中文关键词: 更年期抑郁症 郁病 补肾疏肝法 雌激素缺乏 海马神经元再生 HPO轴 HPA轴 神经递质 |
| English Keywords:Female climacteric depression Depressive illness Tonifying the kidneys and soothing the liver Estrogen deficiency Hippocampal neuron regeneration HPO axis HPA axis Neurotransmitter |
| 基金项目:国家自然科学基金面上项目（81673930）——基于Notch与JAK／STAT信号串话研究卒中后应激大鼠神经重塑及益肾调气中药的干预机制 |
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| 中文摘要: |
| 女性更年期抑郁症（FCD）为现代女性多发病，属于中医“围绝经期综合征”“郁病”范畴。在女性生存压力日渐增高的当下，为了提高女性的生命质量及心理健康，针对FCD的治疗刻不容缓。此期女性机体衰老、卵巢功能下降、雌激素水平急剧波动，加之身体对各种不良应激的耐受能力降低而引发以精神情志不畅、抑郁为主的心境障碍。中医多认为FCD以肾精亏虚为本，肝失疏泄、气机郁结为因。更年期女性雌激素减少，其发挥的脑保护作用降低，与受体结合能力减弱，直接影响海马神经元再生功能，并且导致以生殖功能为主的下丘脑-垂体-卵巢轴紊乱、抗应激下丘脑-垂体-肾上腺轴亢进、单胺类神经递质缺乏等一系列损伤。 |
| English Summary: |
| Female climacteric depression(FCD) is a common modern disease among women，falling within the scope of “perimenopausal syndrome” and “depressive illness” in traditional Chinese medicine.In the face of increasing life stress for women，urgent attention is needed to enhance their quality of life and mental health，focusing on the treatment of FCD.During menopause，women experience aging，ovarian function decline，steep fluctuations in estrogen levels，and reduced tolerance to various stressors，which leads to mood disorders primarily characterized by mental and emotional disturbances，with depression being a prominent feature.Traditional Chinese medicine attributes FCD to a deficiency of kidney essence as the root cause，along with liver dysfunction in dispersing and regulating，and stagnation of qi circulation as contributing factors.The decrease of estrogen in menopausal women reduces its brain-protective effects and weakens its binding capacity to receptors，directly affecting the regeneration function of hippocampus neurons.This hormonal imbalance leads to a series of damages such as the disorder of hypothalamus-pituitary-ovary(HPO) axis，the hyperactivity of hypothalamus-pituitary-adrenal(HPA) axis，and the lack of monoamine neurotransmitters. |
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