Female climacteric depression(FCD) is a common modern disease among women，falling within the scope of “perimenopausal syndrome” and “depressive illness” in traditional Chinese medicine.In the face of increasing life stress for women，urgent attention is needed to enhance their quality of life and mental health，focusing on the treatment of FCD.During menopause，women experience aging，ovarian function decline，steep fluctuations in estrogen levels，and reduced tolerance to various stressors，which leads to mood disorders primarily characterized by mental and emotional disturbances，with depression being a prominent feature.Traditional Chinese medicine attributes FCD to a deficiency of kidney essence as the root cause，along with liver dysfunction in dispersing and regulating，and stagnation of qi circulation as contributing factors.The decrease of estrogen in menopausal women reduces its brain-protective effects and weakens its binding capacity to receptors，directly affecting the regeneration function of hippocampus neurons.This hormonal imbalance leads to a series of damages such as the disorder of hypothalamus-pituitary-ovary(HPO) axis，the hyperactivity of hypothalamus-pituitary-adrenal(HPA) axis，and the lack of monoamine neurotransmitters.