| 引用本文:李沂霖，王花欣，田硕，王洁，董仁超，刘艳秋.补肾中药调控骨髓间充质干细胞成骨分化的RNA m6A修饰作用研究[J].世界中医药,2024,(02):. |
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| 补肾中药调控骨髓间充质干细胞成骨分化的RNA m6A修饰作用研究 |
| Effects of Kidney-tonifying Herbs on Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells from the Perspective of m6A Modification |
| 投稿时间：2022-05-18 |
| DOI：10.3969/j.issn.1673-7202.2024.02.021 |
| 中文关键词: 骨间充质干细胞 N6甲基腺苷修饰 补肾中药 成骨分化 骨质疏松 靶点 作用机制 肾藏象 |
| English Keywords:Bone marrow mesenchymal stem cells m6A modification Kidney-tonifying herbs Osteogenic differentiation Osteoporosis Target Mechanism Visceral manifestation of kidney |
| 基金项目:国家自然科学基金项目（82074134）——二至丸通过Mettl3/14介导m6A动态修饰调控骨髓间充质干细胞成骨分化抗骨质疏松的表观机制 |
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| 中文摘要: |
| 骨髓间充质干细胞（BMSCs）是一种成体干细胞，具有成骨细胞分化能力。BMSCs成骨分化能力减弱易导致骨质疏松等多种骨相关疾病。中医学认为“肾主骨生髓”，补肾中药是治疗骨质疏松的常用药物，具有调控BMSCs成骨分化作用。腺苷N6位甲基化修饰（m6A）是真核生物RNA的转录后修饰，是BMSCs成骨分化的关键因素。探讨m6A动态修饰与BMSCs成骨分化的关系，分析补肾中药调控m6A修饰的可能作用及靶点，能够为补肾中药治疗骨质疏松提供新靶点，为中医肾藏象理论的科学阐释提供思路。 |
| English Summary: |
| Bone marrow mesenchymal stem cells(BMSCs) are adult stem cells with osteogenic differentiation ability.The weakening osteogenic differentiation ability of BMSCs can easily lead to a variety of bone-related diseases，such as osteoporosis.Based on the theory of traditional Chinese medicine that “kidney governs the bone and generates the marrow”，kidney-tonifying herbs are commonly used in the treatment of osteoporosis，which has the effect of regulating osteogenic differentiation of BMSCs.N6-methyladenosine(m6A) is a post-transcriptional modification of eukaryotic RNA and a key factor in osteogenic differentiation of BMSCs.This study explores the relationship between m6A dynamic modification and osteogenic differentiation of BMSCs，and analyzes the possible role and targets of kidney-tonifying herbs in regulating m6A modification，which can provide new targets for kidney-tonifying herbs in the treatment of osteoporosis，and provide ideas for the scientific interpretation of the theory of visceral manifestation of kidney in traditional Chinese medicine. |
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