| 引用本文:李磊1，周锦1，余涛2，张豪荣1，陈辰1，余长艳1，宋海斌3，朱琼洁1.基于治未病理论灸药同治对实体恶性肿瘤化疗患者骨髓抑制的预防作用[J].世界中医药,2024,(03):. |
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| 基于治未病理论灸药同治对实体恶性肿瘤化疗患者骨髓抑制的预防作用 |
| Preventive Effect of Moxibustion Combined with Medication on Myelosuppression in Patients with Solid Malignant Tumors Treated with Chemotherapy Based on Theory of Preventive Treatment of Disease |
| 投稿时间：2023-09-19 |
| DOI：10.3969/j.issn.1673-7202.2024.03.012 |
| 中文关键词: 恶性肿瘤 治未病理论 灸药同治 化疗 骨髓抑制 中医证候积分 血常规 生命质量 |
| English Keywords:Malignant tumor Theory of preventive treatment of disease Moxibustion combined with medication Chemotherapy Myelosuppression TCM syndromes scores Blood routine Quality of life |
| 基金项目:国家自然科学基金项目（81704023）——抑癌方通过COX-2调控VE-Cadherin信号通路干预大肠癌血管拟态形成的机制研究；武汉市卫生健康委科研项目（WZ21C59）——基于治未病理论探讨灸药同治对化疗后骨髓抑制的影响 |
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| 中文摘要: |
| 目的：基于治未病理论探讨灸药同治对实体恶性肿瘤化疗患者骨髓抑制的预防作用。方法：选取2019年1月至2022年1月于武汉科技大学附属武汉亚心总医院接受治疗的实体恶性肿瘤化疗患者120例作为研究对象，采用随机数字表法分为对照组和观察组，每组60例。对照组常规接受化疗，观察组化疗前连续3 d给予灸药同治（艾灸+加味八珍汤）。比较治疗前、化疗后7 d 2组患者中医证候积分、血常规[血红蛋白（Hb）、白细胞计数（WBC）、血小板计数（PLT）、中性粒细胞计数（NEUT）]、生命质量[卡诺夫斯凯计分KPS）、中国癌症患者生命质量（QOL2）调查问卷]，比较化疗后7 d 2组患者骨髓抑制情况[发生率、严重程度、重组人粒细胞集落刺激因子（rhG-CSF）使用情况]。结果：化疗后7 d，2组患者中医证候积分升高，但观察组低于对照组（P<0.05）；Hb、WBC、PLT、NEUT、KPS评分及QOL2评分降低，但观察组高于对照组（均P<0.05）；观察组骨髓抑制发生率、rhG-CSF使用率低于对照组，0、Ⅰ度比例高于对照组（均P<0.05）。结论：基于治未病理论，灸药同治能够改善实体恶性肿瘤化疗患者临床症状及血常规，提高患者生命质量，减少骨髓抑制的发生。 |
| English Summary: |
| To explore the preventive effect of moxibustion combined with medication on myelosuppression in patients with solid malignant tumors undergoing chemotherapy based on the theory of preventive treatment of disease.Methods:A total of 120 patients with solid malignant tumors undergoing chemotherapy at Wuhan Asia Heart Hospital affiliated to Wuhan University of Science and Technology from January 2019 to January 2022 were enrolled and randomly divided into a control group and an observation group，with 60 cases in each group.The control group received routine chemotherapy，while the observation group received moxibustion combined with medication for 3 consecutive days before chemotherapy(moxibustion+modified Bazhen Decoction).The traditional Chinese medicine(TCM) syndrome scores，blood routine parameters [hemoglobin(Hb)，white blood cell count(WBC)，platelet count(PLT)，and neutrophil count(NEUT)]，and quality of life [Karnofsky Performance Status(KPS) score and Quality of Life Questionnaire for Cancer Patients(QOL2)] were compared between the two groups before chemotherapy and at 7 days after chemotherapy.Myelosuppression status [incidence rate，severity，and use of recombinant human granulocyte colony-stimulating factor(rhG-CSF)] was compared between the two groups at 7 days after chemotherapy.Results:At 7 days after chemotherapy，the TCM syndrome scores of both groups increased，but the observation group was lower than the control group(P<0.05).Hb，WBC，PLT，NEUT，KPS score，and QOL2 score decreased，but were higher in the observation group than in the control group(all P<0.05).The incidence rate of myelosuppression and the utilization rate of rhG-CSF in the observation group were lower than those in the control group，and the proportion of grade 0 and grade I myelosuppression was higher than that in the control group(all P<0.05).Conclusion:Based on the theory of preventive treatment of disease，moxibustion combined with medication can improve clinical symptoms and blood routine parameters，enhance the quality of life of patients with solid malignant tumors undergoing chemotherapy，and reduce the incidence of myelosuppression. |
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