To explore the clinical efficacy and safety of topical application of TongXin Bi Ointment at acupoints combined with auricular acupressure bean-pressing in the treatment of stable angina pectoris of coronary heart disease(heat toxin phlegm stasis，qi and yin deficiency).Methods:A total of 120 hospitalized chronic stable angina pectoris(CSAP) patients with heat-toxin phlegm stasis，deficiency of both qi and yin from June 2020 to June 2021 at the Clinical School of Traditional Chinese Medicine，Yangzhou University(Yangzhou Traditional Chinese Medicine Hospital) were selected as the study subjects and randomly divided into the treatment group and the control group using SPSS 21.0 software，with 60 cases in each group.The control group was given conventional western medicine treatment，and the observation group received TongXinBi Ointment at acupoints combined with auricular acupressure bean-pressing on the basis of basic treatment.The frequency and duration of angina pectoris attack，TCM symptom score，serum high-sensitivity C-reactive protein level，and blood lipid level were analyzed as relevant observation indicators before and after treatment in the two groups to evaluate the clinical comprehensive efficacy; the general physical signs，liver and kidney function，hematuria and stool，adverse reactions and other indicators were analyzed for safety.Results:Both treatment regimens were effective for CSAP patients，and the clinical comprehensive efficacy of the observation group was superior to that of the control group(P<0.05).The frequency and duration of angina pectoris attack，TCM symptom score，serum high-sensitivity C-reactive protein and serum total cholesterol，triglyceride，low-density lipoprotein decreased levels of the observation group were better than those of the control group(P<0.05)，and the serum high-density lipoprotein increased levels of the observation group were not different from those of the control group(P>0.05).Conclusion:The combination of topical application of TongXinBi Ointment at acupoints combined with auricular acupressure bean-pressing can improve the clinical symptoms of CSAP patients with heat-toxin phlegm stasis，deficiency of both qi and yin.This approach enhances the quality of life for patients，and play a role in reducing the levels of serum high-sensitivity C-reactive protein，serum total cholesterol，triglycerides，low-density lipoprotein in patients.Moreover，the treatment demonstrates favorable economic feasibility，warranting further clinical promotion.