世界中医药

目的：观察俞募配穴针刺治疗肝郁脾虚型抑郁症患者的临床疗效。方法：选取2022年1月至2022年12月福建中医药大学附属第二人民医院收治的肝郁脾虚型抑郁症患者100例作为研究对象，随机分为对照组和观察组，每组50例。对照组给予艾司西酞普兰口服治疗，持续用药1个月；观察组在对照组基础上联合俞募配穴针刺治疗，2 d治疗1次，持续治疗15次。比较2组患者治疗前后主要症状、抑郁程度、生命质量评分、血清5-羟色胺（5-HT）水平、肠道菌群、不良反应、复发率及临床疗效。结果：治疗后，观察组健康调查简表（SF-36）评分、血清5-HT水平、粪便标本乳酸杆菌及双歧杆菌数量高于对照组（均P<0.05），主要症状评分、汉密尔顿抑郁量表（HAMD-24）评分、粪便标本大肠埃希菌及肠球菌数量低于对照组（均P<0.05）。2组患者不良反应发生率比较差异无统计学意义（P>0.05）。观察组治疗后6个月复发率略低于对照组，但差异无统计学意义（P>0.05）。治疗后观察组总有效率高于对照组（P<0.05）。结论：俞募配穴针刺治疗肝郁脾虚型抑郁症患者疗效明确，可有效改善患者症状，减轻抑郁程度，提高生命质量，调节血清5-HT水平及改善肠道菌群分布，安全性高。

English Summary:

To observe the clinical efficacy of acupuncture at back-shu and front-mu acupoints in the treatment of depression patients with liver depression and spleen deficiency syndrome.Methods:A total of 100 patients diagnosed with depression with liver depression and spleen deficiency syndrome treated at the Second Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine from January 2022 to December 2022 were enrolled and randomly divided into control group and observation group，with 50 cases in each group.The control group was treated with oral administration of escitalopram for one month，while the observation group were treated with acupuncture at back-shu and front-mu acupoints based on the control group，with treatment administered once every 2 days for a total of 15 times.The main symptoms，depression severity，quality of life scores，serum 5-hydroxytryptamine(5-HT) levels，intestinal flora，adverse reactions，recurrence rate，and clinical efficacy were compared before and after treatment between the two groups.Results:After treatment，the observation group had higher scores in the Short Form Health Survey(SF-36)，serum 5-HT levels，and quantities of Lactobacillus and Bifidobacterium in fecal specimens than the control group(all P<0.05)，while the scores of main symptoms，Hamilton Depression Rating Scale(HAMD-24)，and quantities of Escherichia coli and Enterococcus in fecal specimens were lower than those in the control group(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate in the observation group at 6 months after treatment was slightly lower than that in the control group，but the difference was not statistically significant(P>0.05).The total effective rate in the observation group after treatment was higher than that in the control group(P<0.05).Conclusion:Acupuncture at back-shu and front-mu acupoints has definite efficacy in the treatment of depression patients with liver depression and spleen deficiency syndrome，effectively improving symptoms，reducing depression severity，enhancing quality of life，regulating serum 5-HT levels，and improving intestinal flora distribution，with high safety.

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