To study the effect of Fuzheng Touxie Jiedu Huayu Formula on inflammatory responses and immune function in elderly rats with pneumonia caused by multi-drug-resistant Pseudomonas aeruginosa.Methods:The experimental elderly rats were randomly divided into six groups：blank control group，model control group，western medicine control group，traditional Chinese medicine(TCM) group，pre-medication TCM group，and integrated traditional Chinese medicine and western medicine treatment group.The study dynamically observed changes in inflammation markers and lymphocyte proliferation levels at different time points across the groups.Results:Significant therapeutic effects were observed in both the pre-medication TCM group and the integrated treatment group，and the TCM group showed notable improvements in early-stage inflammation levels; the integrated treatment group helped T lymphocyte proliferation approach normal levels; the pre-medication TCM group and the integrated treatment group were able to suppress post-infection B lymphocyte proliferation and normalize it.Conclusion:Fuzheng Touxie Jiedu Huayu Formula can modulate the excessive immune-inflammatory reaction of elderly rats in the early stage of infection，and the integrated traditional Chinese and western medicine treatment can correct the disordered immune state after infection with multidrug-resistant P.aeruginosa.Pre-medication of TCM can play a preventive and therapeutic role in the inflammation and immune dysregulation following such infections.