The theory of five circuits and six qi is an important thought of the unity of man and nature in the Huangdi's Internal Classic(Huang Di Nei Jing)，as well as a major feature of TCM thinking and an important embodiment of the scientific nature of TCM.The Case Records as a Guide to Clinical Practice(Lin Zheng Zhi Nan Yi An) encompasses the valuable experience of Ye Tianshi in the diagnosis and treatment of apoplexy and his experience in the application of the theory of five circuits and six qi.Ye believes that when wind-wood dominates the heavens，qi and fire are easily hyperactive，which will restrain the spleen and soil and obstruct qi movement，while in the year of celestial correspondence when the climate changes dramatically，apoplexy occurs due to the release of yang qi and failure of keeping yin in interior.The occurrence of apoplexy is related to seasonal qi.The overlapping of the time dominated by Jueyin wind-wood and heat-fire qi will consume qi and fluid.The abnormal distribution of qi and fluid empties collaterals，resulting in apoplexy.The abnormal warm days in winter will lead to the failure of kidney in storing and consume kidney yin，leading to the symptoms of apoplexy.In view of the above pathogenesis，middle qi should be replenished when Jueyin is dominant and the spleen and stomach are affected by pathogen，and at the same time，the astringent and descending medicinals should be used to regulate the ascending but not descending qi in the human body.In the season when heat-fire is dominant and yang qi is released，spleen and stomach should be tonified to strengthen the defense qi for those who suffer from apoplexy due to empty collaterals.In winter with abnormal warm days，those who suffer from apoplexy due to insecurity of kidney essence could be treated by nourishing water and wood.Ye attached great importance to the influence of external environmental factors on pathogenesis and adopted the idea of correspondence between man and nature to diagnose and treat apoplexy，which is worth research and learning.