Chronic Hepatitis B is a chronic inflammatory liver disease caused by persistent infection of hepatitis B virus，characterized clinically by fatigue，loss of appetite，abdominal distension and abdominal pain.Professor XIE Jingri believes that the overall pathogenesis of chronic hepatitis B involves the deficiency of healthy qi，and dampness-heat and pestilential toxin stagnate in the liver and spleen，eventually leading to a complex interplay of damp-heat and stasis toxins，resulting in damage to the liver，spleen and kidney.Professor XIE points out that the liver as the initial site affected，subsequently involving spleen，kidney，gallbladder，and stomach，indicative of a mixed pattern of deficiency in root and excess in manifestation.In terms of treatment，Professor XIE puts forward the unique treatment methods of “invigorating spleen and stomach to protect the foundation”“clearing heat and removing toxin，and dispelling dampness”“activating blood and dispelling stasis，and dredging the collaterals of liver gently”.His pharmacological approach combines cooling and warming properties，bitter and sweet flavors，and pungent herbs that disperse Qi and blood，achieving harmony between liver and spleen.Commonly used herbs include Radix Bupleuri，Radix Astragali，Rhizoma Atractylodis，Radix Pseudostellariae，Pericarpium Citri Reticulatae，Chicken's Gizzard-membrane，Forsythia suspensa，Radix Isatidis，Herba Hyperici Japonici，Silybum Marianum，Rhizoma Alismatis，Polyporus umbellatus，Rhizoma Sparganii，Rhizoma curcumae，Rhizoma Corydalis，and Szechuan Lovage Rhizome.Professor Xie's thinking of pattern differentiation is clear，with flexible modification of prescriptions and significant clinical outcomes.Supporting case 1 is attached to demonstrate the efficacy of these approaches.